血游离三碘甲状腺原氨酸与冠状动脉钙化程度的相关性及对主要心血管事件的影响

Study of blood three free triiodothyronine and coronary artery calcification degree of correlation and impact on major cardiovascular events

目的分析血游离三碘甲状腺原氨酸（FT3）与冠状动脉钙化程度相关性及对主要心血管事件的影响。方法回顾性分析2014年1月至2015年11月可疑冠心病患者120例临床资料,所有患者均行FT3、冠状动脉双源CT检测,根据患者FT3水平分为两组,对照组正常FT3患者62例,研究组低FT3患者58例,根据冠状动脉钙化积分（CACS）分为两组,CACS≤100分组75例,CACS〉100分组45例;对所有患者进行8~30个月随访,记录不良心血管事件（MACE）发生情况,并采用Logistic回归分析冠状动脉钙化、MACE相关因素。结果研究组MACE15.52%显著高于对照组的3.23%（P100分组MACE15.56%、显著高于CACS≤100分组2.67%,FT3（3.89±0.58）pmol/L显著低于CACS≤100分组（4.34±0.61）pmol/L（P〈0.05）;Logistic回归分析显示：FT3水平与冠状动脉钙化、MACE均相关（OR=0.442、OR=0.366,P〈0.05）。结论血FT3与冠状动脉钙化程度紧密相关相关,低FT3水平是心血管事件发生危险因素,冠状动脉钙化程度越重,心血管事件发生几率越高。

Objective To analyze blood FT3 and severity of coronary artery calcification and influence of major cardiovascular events. Methods A retrospective analysis of outpatients suspicious clinical data of 120 patients with coronary heart disease. All patients underwent FT3,dual-source CT coronary testing. The patients were divided into two groups according to the level of FT3,the control group（ 62 cases） with normal FT3,and research group with low FT3（ 58 patients）. According to the coronary artery calcium score（ CACS）,patients were divided into two groups,CACS≤100 group（ 75 cases）,CACS 100 group（ 45 cases）; during 8- 30 months follow- up,record the occurrence of adverse cardiovascular events,and perform logistic regression to analyze the relationship of coronary artery calcification,MACE relevant factors. Results MACEin the study group was 15. 52%,significantly higher than the control group 3. 23%（ P〈0. 05）. MACE in CACS 100 packets（ 5. 56%）,was significantly higher than CACS≤100 packet（ 2. 67%）,FT3（ 3. 89 ± 0. 58） pmol / L was significantly lower than that（ 4. 34 ± 0. 61） pmol / L（ P〈0. 05）. Logistic regression analysis showed that： FT3 levels and coronary artery calcification,MACE were associated（ OR = 0. 442,OR = 0. 366,P〈0. 05）.Conclusion Blood FT3 and severity of coronary artery calcification is closely related,and low FT3 level is risk factors for cardiovascular events.More severe the coronary artery calcified,the higher the probability of cardiovascular events.