磁共振T1ρ在大鼠肝纤维化模型中的应用价值

Application of MRI with T1 Relaxation Time in the Rotating Frame in Liver Fibrosis in Rats

目的研究磁共振T1ρ在肝纤维化进程中的变化特征,探讨T1ρ在肝纤维化大鼠模型中的应用价值。方法 SD大鼠65只(对照组15只,模型组50只),模型组采用四氯化碳诱导不同时间以获取不同程度的肝纤维化。使用3.0T磁共振应用5个自旋锁定时间获得T1ρ值。扫描后行肝脏病理学检查,将影像结果与病理结果行对照分析。结果 5只大鼠在造模过程中死亡,60只大鼠纳入分析,肝纤维化各期的T1ρ值在5组间整体比较差异有统计学意义(P<0.05)。单因素方差分析,T1ρ值在F1期和F2期之间没有差异,在其余各期之间均有统计学差异。相关性分析结果为T1ρ值与肝纤维化程度呈正相关(r=0.863,P<0.05)。结论磁共振T1ρ可以作为一种无创、敏感的新技术用于探测肝肝纤维进程中病理及生理改变,有助于早期检测和定量诊断肝纤维化。

Objective To explore the value of T1 relaxation times in the rotating frame（T1ρ or T1rho） for liver fibrosis. Methods Liver fibrosis model rats（N=50） were produced by carbon tetrachloride（CCl4） injection. Five rats died during the experiment. Surviving model rats（N=45） and controls（N=15） were subjected to 3.0-T MRI and T1ρ values were determined. Liver fibrosis stage（F0–F4） was defined based on METAVIR scoring. Results T1ρ values associated positively（r=0.863,P〈0.05） with severity of fibrosis stage. Conclusion T1ρ may be a new kind of noninvasive technique to show the changes of liver in pathology and histology during the progression of fibrosis.