GALNTL5对精子发生的影响

GALNTL5 and Spermatogenesis

GALNTL5是近年来新发现的一个在睾丸中特异性表达,并参与精子发生的重要蛋白。GALNTL5的突变可导致雄性患弱精症,影响雄性生育能力。因此,GALNTL5基因可作为候选基因,阐述相关雄性先天性不育的部分病因。论文简要介绍了GALNTL5的结构与功能及其突变对精子发生产生的生物学影响。

GALNTL5 is a newly found important protein which is specifically expressed in testes and participates in spermatogenesis.The mutation of GALNTL5 may cause male asthenospermia and affect male fertility.Therefore,partial reasons for male congenital infertility may be explained with GALNTL5 as a candidate gene.This paper briefly introduces the structure and function of GALNTL5 and the biological effect of its mutation on spermatogenesis.