子宫肌瘤发病相关危险因素分析

A study on risk factors for uterine leiomyomas

目的研究郑州市子宫肌瘤患者发病的危险因素。方法选择2014年8月至2015年3月于郑州大学第三附属医院确诊的160例子宫肌瘤患者作为病例组,选择同期在该院就诊的160例健康体检者作为对照组,采用病例对照研究方法对研究对象进行流行病学问卷调查,将结果录入数据库,对资料进行单因素和多因素Logistic回归分析。结果单因素分析显示,体质量指数、接触化妆品、食用豆浆及蜂蜜、初潮年龄、月经紊乱、流产次数、口服避孕药在病例组与对照组间的差异均有统计学意义(P<0.05);多因素回归分析显示,食用豆浆、初潮年龄、月经紊乱、流产次数、口服避孕药与子宫肌瘤发病有关。结论食用豆浆、初潮年龄早、月经紊乱、流产次数多、服用口服避孕药可能是子宫肌瘤发病的危险因素。

Objective To study the risk factors for uterine leiomyoma. Methods 160 patients with uterine leiomyoma confirmed by the Third Affiliated Hospital of Zhengzhou University from August of 2014 to March of 2015 were selected as the case group,while 160 healthy volunteers were selected as the control group during the same period. Case- control study method was adopted to make the questionnaire survey of epidemiology on all of the research objects. The results were recorded into the database and the materials were analyzed through univariate or multivariate unconditional logistic regression analysis. Results Univariate unconditional regression analysis showed that BMI,exposure to cosmetics,consumption of soybean milk and honey,menarchal age,menstrual disorder,abortion times,taking oral contraceptive had statistically significant differences between case group and control group. Multivatiate unconditional regression analysis indicated that consumption of soybean milk,menarchal age,menstrual disorder,abortion times and taking oral contraceptive were related with uterine leiomyoma. Conclusion Consumption of soybean milk,early age at menarche,menstrual disorder,abortion times and taking oral contraceptive may be the risk factors for uterine leiomyoma.