紫杉醇联合奈达铂治疗晚期食管癌的临床效果观察

Clinical efficacy of paclitaxel combined with nedaplatin in the treatment of advanced esophageal cancer

目的观察紫杉醇联合奈达铂方案治疗晚期食管癌的临床疗效和毒副反应。方法选取36例晚期食管癌患者,应用紫杉醇联合奈达铂方案化疗,紫杉醇150 mg/m^2,第l天,奈达铂25 mg/m^2,第2~4天;21 d为1个周期,2个周期后评价临床疗效和毒副反应。结果完全缓解1例(2.8%),部分缓解16例(44.4%),稳定11例(30.6%),疾病进展8例(22.2%),总有效率为47.2%(17/36)。毒副反应主要表现为血液学毒性、消化道反应、神经毒性和脱发,但是可耐受,于对症处理或化疗结束后均能缓解。结论紫杉醇联合奈达铂治疗晚期食管癌疗效确切,毒副反应较轻,可用于晚期食管癌的治疗,且更适合老年或体质较差患者。

Objective To observe the clinical efficacy and toxicity of paclitaxel combined with nedaplatin in the treatment of advanced esophageal cancer. Methods 36 cases of advanced esophageal cancer treated with paclitaxel combined with nedaplatin. The chemotherapy regimens： paclitaxel with 150 mg / m^2 on the first day,nedaplatin with 25 mg / m^2 from the second day to the forth day; 21 days for 1 cycle. The efficacy and toxicity were evaluated after 2 cycles. Results There were 1 case（ 2. 8%）of complete remission,16 cases（ 44. 4%） of partial remission,11 cases（ 30. 6%） of stable state,and 8 cases（ 22. 2%） of disease progression. The total effective rate was 47. 2%（ 17 /36）. The main manifestations of toxic side effects were hematological toxicity,gastrointestinal reaction,neurotoxicity and hair loss,but they could be tolerated and alleviated after the symptomatic treatment or chemotherapy. Conclusion The therapeutic effect of paclitaxel combined and nedaplatin in the treatment of advanced esophageal cancer is accurate with less toxic side effects. It can be used for the treatment of advanced esophageal cancer,and more suitable for the aged or patients with weak constitution.