期刊文献+

乳腺癌分子分型在ET方案化疗敏感性及预后方面的预测作用 被引量:2

下载PDF
导出
摘要 目的探讨乳腺癌分子分型在表阿霉素与多烯紫杉醇联合治疗的方案(ET方案)化疗敏感性及预后方面的预测效果。方法选取乳腺癌患者54例,根据免疫组化法对患者组织标本进行分子分型,10例为HER 2+亚型,37例为Luminal型,7例为Basal-like亚型,安排3组患者共同接受ET化疗治疗,观察化疗疗效及无病生存率、总生存率。结果 HER 2+亚型病理完全缓解率为30.00%,无病生存率为60.00%,总生存率为70.00%;Luminal型病理完全缓解率为10.81%,无病生存率为70.27%,总生存率为81.08%;Basal-like亚型病理完全缓解率为28.57%,无病生存率为28.57%,总生存率为71.43%。结论在乳腺癌ET方案化疗治疗中,不同分子分型,敏感性与预后效果均有所差异,在病理完全缓解预测中具有一定的价值。
作者 张进儒
出处 《当代医学》 2016年第12期60-61,共2页 Contemporary Medicine
  • 相关文献

参考文献8

二级参考文献105

  • 1Elston CW,Ellis IO.Pathologica prognostic factors in breast cancer.I.The value of histological grade in breast cancer:Experience from a large study with long-term follow-up[J].Histopathology,1991,19(5)403.
  • 2Nielsen TO,Hus FD,Jensen K,et al.Immunohistochemical and clinical characterization of the basal-like subtype of invasive breast carcinoma[J].Clin Cancer Res,2004,10(16):5367.
  • 3Perou CM,Sorlie T,Eisen MB,et al.Molecular portraits of human breast tumours[J].Nature,2000,406:747.
  • 4Carey LA,Peron CM,Livasy CA,et al.Race,breast cancer subtypes,and survival in the Carolina Breast Cancer Study[J].JAMA,2006,295:2492.
  • 5Kim M J,Ro J Y,Ahn S H,et al.Clinicopathologic significance of the basal-like subtype of breast cancer:A comparison with hormone receptor and HER2/neu-overexpression phenotype[J].Hum Pathol,2006,37:1217.
  • 6Hu ZY,Fan C,Oh DS,et al.The molecular portraits of breast tumors are conserved across microarray platforms[J].BMC Genomics,2006,7:96.
  • 7Conforti R,Boulet T,Tmasic G,et al.Breast cancer molecular subclassification and estrogen receptor expression to predict efficancy of adjuvant anthracyclines-based chemotherapy:A biomarker study from two randomized trials[J],Ann Oncol,2007,18(9):1477.
  • 8Dent R,Trudeau M,Pritchard KI,et al.Triple-negative breast cancer;Clinical features and patterns of recurrence[J].Clin Cancer Res,2007,13(15Pt1):4429.
  • 9Cleator S,Heller W,Coombes RC.Triple-negative breast cancer therapeutic options[J].Lancet Oncol,2007,8(3),235.
  • 10Carey L A,Dees E C,Sawfy L,et al.The Triple negative paradox:Primary tumor chemosensitivy of breast cancer subtypes[J].Clin Cancer Res,2007,13(8):2329.

共引文献208

同被引文献21

引证文献2

二级引证文献16

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部