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肠道病毒71型与天然免疫系统相互作用的研究进展 被引量：6

Progress on interactions between enterovirus 71 and innate immunity
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摘要 肠道病毒71型(enterovirus 71,EV71)为小RNA病毒科肠道病毒属成员,是引起手足口病的主要病原体之一。EV71流行广泛,其感染可引发中枢神经系统疾病,并造成重症手足口病,给公共卫生安全带来极大挑战。EV71的致病机制与病毒和宿主天然免疫系统的相互作用关系密切,涉及病毒逃逸干扰素反应、病毒抑制核因子κB(nuclear factorκB,NF-κB)信号通路及病毒与天然免疫细胞相互作用等多个环节。本文就近年来EV71与宿主天然免疫系统相互作用的研究进展进行综述。 Enterovirus 71（EV71）is a pathogen for hand,foot and mouth disease（HFMD）,and its prevalence is a great challenge to public health.Pathogenesis of EV71 is closely related to a panel of host innate immune responses,such as escape of interferon response,suppression of nuclear factor κB（NF-κB）signaling pathway and interactions between virus and innate immune cells.This review focuses on the new progress on interactions between EV71 and host innate immunity.
作者 张小龙 李琦涵
机构地区 中国医学科学院/北京协和医学院医学生物学研究所
出处 《微生物与感染》 2016年第2期122-128,共7页 Journal of Microbes and Infections
基金 北京协和医学院"协和青年基金"(3332015051)
关键词 肠道病毒71型 天然免疫 手足口病 Enterovirus 71 Innate immunity Hand foot and mouth disease
分类号 R392 [医药卫生—免疫学]
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参考文献56

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微生物与感染
2016年 第2期

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