西咪替丁对高原昏迷应激性上消化道出血的防治作用

EFFECTS OF CIMETIDINE ON HAMORHAGE OF UPPER DIGESTIVE TRACT INDUCED-ALTITUDE COM

目的 :了解西咪替丁静脉滴注防治高原昏迷应激性上消化道出血的效果 ;方法 :将 71例高原昏迷患者随机分为两组 ,治疗组用西咪替丁 80 0mg/ 2 4h ,静脉滴注 ,根据并发上消化道出血情况测定胃液 pH值及胃液隐血试验 ;另一组为对照组 ;结果 :治疗组胃液pH值 4～ 6,上消化道出血率为 1 1 .3 2 % ;对照组胃液 pH值 2～ 3 ,上消化道出血率为44 .44 % ,P <0 .0 1 ;结论 :西咪替丁静脉滴注能有效降低高原昏迷应激性上消化道出血的发生 ,且应用愈早效果愈好。

Objective: To study the effects of Cimetidine on upper digestive tract hemorrhage in patients with high altitude coma. Method: All 71 subjects were randomly divided into test group ( Cimetidine infusion,800mg/24h) and control group. The level of pH and occult blood in gastric juice and other indices were examined while treatment of high altitude coma. Results: The bleed rate of upper digestive trace, level of gastric juice pH in test group and control group were 11.32%, 4～6 and 44.44%, 2～3 respectively.Conclusion: The hemorrhage of upper digestive tract could be decreased by treatment of Cimetidine in patients with high altitude coama.