脑-肠-微生物群轴与帕金森病

Brain-gut-microbiota axis and Parkinson's disease

帕金森病(Parkinson’s disease,PD)是一种神经退行性疾病,其典型的病理特点是α-突触核蛋白非正常地聚积在脑-肠轴的各级组织内。临床和神经病理学证据表明帕金森神经退行性变化往往伴有消化道症状,且先于中枢神经系统的损伤,同时发现肠道菌群紊乱与PD间存在密切的关系。为此,更好地了解大脑-肠道-微生物群轴的交互作用,明确肠微生物群改变与PD发病间的时间关系和因果关系,将有助于深刻理解PD的发病机制,并为PD的治疗和诊断提供新的作用靶点。

Parkinson＇s disease（ PD） is a progressive neurodegenerative disorder typified by the presence of intraneuronalinclusions containing aggregated alpha-synuclein（ α-syn） affecting all levels of the brain-gut axis. Both clinical and neuropathologicalevidences indicate that neurodegenerative change sin PD are accompanied by gastrointestinal symptoms that may precede or follow the central nervous system impairment. Dysregulation of the brain-gut-microbiotaaxis may significantly contribute to the pathogenesis of PD. The close relationship between gut dysbiosis,intestinal permeability and neurological dysfunction suggests that the gut microbiota modification may provide a promising therapeutic option in PD.