控制性超促排卵患者卵泡液中SDF-1及VEGF水平测定及其与OHSS发病的相关性分析

The correlation between the concentration of SDF-1 and VEGF and the ovarian hyperstimulation syndrome

目的:分析控制性超促排卵患者卵泡液中基质细胞衍生因子-1(SDF-1)和血管内皮生长因子(VEGF)的相关性,初步探讨SDF-1在卵巢过度刺激综合征(OHSS)发生中的作用。方法:选取因输卵管因素或男性因素行IVF/ICSI助孕治疗的72例患者。根据Golen标准分组:中、重度OHSS组26例(A组),无或轻度OHSS者46例(B组),ELISA法检测卵泡液中SDF-1、VEGF水平并进行相关性分析。结果:中、重度OHSS组的卵泡液SDF-1和VEGF水平为(3976.26±3150.92)pg/ml和(171.02±94.56)pg/ml,均显著高于无或轻度OHSS组[(1615.5±1542.68)和(126.23±86.32)pg/ml],差异有统计学意义(P=0.001,P=0.045)。中、重度OHSS组患者卵泡液中SDF-1与VEGF浓度和血清HCG日E2浓度有相关性(r=0.457,P=0.019;r=0.261,P=0.027)。结论:SDF-1可能参与或促进了OHSS的发生发展。

Objective： To investigate the action of SDF-1 on the ovarian hyperstimulation syndrome（OHSS） by analyzing the correlation between stromal cell-derived factor-1（SDF-1） and vascular endothelial growth factor（VEGF） in follicular fluid（FF）.Methods：The levels of SDF-1 and VEGF in FF of 26 patients as Group A（moderate to severe OHSS）and 46 as Group B（mild or no OHSS; control group） undergoing IVF-ET/ICSI-ET were analyzed with Enzyme-linked immunoadsordent assay（ELISA）.Results： The concentrations of SDF-1 and VEGF in Group A were（3976.26 ±3150.92） pg / ml,（171.02 ±94.56） pg / ml,significantly different from that in Group B [（1615.5 ± 1542.68） pg / ml,（126.23 ± 86.32） pg /ml]（P = 0.001,P = 0.045）.The correlation coefficients between SDF-1 and VEGF in Group A and B were 0.457 and 0.167（P = 0.019,P = 0.267）,respectively.The correlation coefficient between the FF concentration of SDF-1 and serum concentration of estrogen was 0.261（P =0.027）.Conclusion： The SDF-1 may promote the development of OHSS.