1Melo J,Toczyski D. A unified view of the DNA-damage checkpoint. Curr Opin Cell Biol,2002,14(2): 237.
2Sanehez Y,Wong C,Thoma RS,et al. Conservation of the Chkl checkpoint pathway in mammals: linkage of DNA damage to Cdkregulation through Cde25. Seience,1997,277 (5331): 1497.
3Zaehos G,Rainey MD,Gillespie DA. Chkl-defieient tumour cells are viable but exhibit multiple checkpoint and survival defects.EMBO J, 2003,22 (3): 713.
5Janetka JW,Ashwell S.Checkpoint kinase inhibitors: a review of thepatent literature. Expert Opin Ther Pat,2009,19(2):165.
6Lu YP,Lou YR,Peng QY,et al.Caffeine decreases phospho- Chkl (Ser317)and increases mitotic cells with cyclin B1 and caspase 3 intumors from UVB-treated mice.Cancer Prey Res (Phila) ,2011,4(7):1118.
7Tibbetts RS,Brumbaugh KM,Williams JM,et al. A role for ATR in the DNA damage-induced phosphorylation of p53. Genes Dev, 1999,13(2): 152.
8Heffernan TP,Simpson DA,Frank AR,et al. An ATR-and Chkl-dependent S checkpoint inhibits replicon initiation following UVC-induced DNA damage. Mol Cell Biol,2002,22 (24):8552.
9Peng CY,Graves PR,Thoma RS,et al.Mitotic and G2 checkpointcontrol: regulation of 14-3-3 protein binding by phosphorylation of Cdc25C on serine-216.Science,1997,277 (5331): 1501.
3American Cancer Society. Cancer facts and figures 2005[M]. Atlanta: Ga. American Cancer Socirty, 2005. 122-124.
4Bartek J, Lukas J. Chkl and Chk2 kinases in checkpoint control and cancer[J]. Cancer Cell, 2003, 3(5) : 421-429.
5Smits VA, KlompmakerR, Arnaud L, et al. Polo-like kinase-1 is a target of the DNA damage checkpoinl[J]. Nat Cell Biol. 2000, 2(9): 672-676.
6Zhou BB, Bartek J. Targeting the checkpoint kinases: hemosensitization versus ehemoprotection[J]. Nat Rev Cancer, 2004, 4(3) :216-225.
7Takai N, Hamanaka R, Yoshimatsu J, et al. Polo-like kinases (Plks) and cancer[J]. Oncogene,2005, 24(2): 287-291.
8Weichert W, Denkert C, Schmidt M, et al. Polo-like kinase isoform expression is a prognostic factor in ovarian carcinoma [J]. Br J Cancer. 2004, 90(4) : 815-821.
9Pavla Hublarova,Kristina Greplova,Jitka Holcakova,Borivoj Vojtesek,Roman Hrstka.Switching p53-dependent growth arrest to apoptosis via the inhibition of DNA damage-activated kinases[J]. Cellular & Molecular Biology Letters . 2010 (3)
10Leander Gaul,Sonja Mandl-Weber,Philipp Baumann,Bertold Emmerich,Ralf Schmidmaier.Bendamustine induces G2 cell cycle arrest and apoptosis in myeloma cells: the role of ATM-Chk2-Cdc25A and ATM-p53-p21-pathways[J]. Journal of Cancer Research and Clinical Oncology . 2008 (2)
