皮质醇与代谢综合征研究进展

Research Advance of Relationship between Cortisol and Metabolic Syndrome

代谢综合征是表现为中心性肥胖、高血脂、高血压以及高血糖的一组临床症候群,近年来其发病率逐年升高。众所周知,皮质醇增多是库欣综合征的病理生理基础。因库欣综合征与代谢综合征在症状、体征、生化表现等临床特征上有诸多相似之处,有越来越多的研究旨在揭示皮质醇与代谢综合征的密切联系,同时为代谢综合征的防治提供新的思路。本文介绍了代谢综合征与下丘脑-垂体-肾上腺轴、11β-羟类固醇脱氢酶、皮质醇水平及功能等的关系及其研究现状。

The metabolic syndrome（ MS） is a cluster of metabolic abnormalities and is characterized by central obesity,hyperlipidemia,hypertension,diabetes or impaired glucose tolerance. Recent years,the worldwide incidence of MS has been significantly increased. It is well known that cortisol excess is the physiopathological basis of Cushing syndrome. The similarities between the clinical features of Cushing syndrome and those of MS raised the hypothesis that MS is associated with glucocorticoids excess,suggesting that cortisol may play a key role in MS,which might lead to an improved understanding in prevention and cure for MS. In this paper,the recent research advance of relationship between MS and hypothalamic-pituitary-adrenal（ HPA） axis,11β-hydroxysteroid dehydrogenase（ 11β-HSD） and levels and functions of cortisol is reviewed.