肠内营养粉安素对终末期恶性肿瘤患者营养状况和糖脂代谢的影响

Effects of Enteral Nutrition Powder Ensure on Nutritional Status and Glucolipid Metabolism in Patients with End-Stage Malignant Tumors

目的观察肠内营养粉安素对终末期恶性肿瘤患者营养状况、糖脂代谢的影响。结果选取2012年8月至2014年8月收治的终末期恶性肿瘤患者78例,入院后28~72 h根据患者及家属是否自愿接受鼻空肠管置管行肠内营养支持分为观察组（42例）和对照组（36例）,观察组给予肠内营养粉安素,对照组给予普通流质食物,持续30 d。评估两组营养状况、血糖及血脂、肿瘤患者生活质量评分（QOL）。结果观察组治疗后白蛋白、前白蛋白、转铁蛋白显著高于对照组[（30.16±4.11）g/L比（22.11±3.69）g/L,（331.64±26.34）mg/L比（285.52±27.85）mg/L,（2.94±0.58）mg/L比（2.06±0.71）mg/L,P〈0.05]。观察组治疗后糖化血红蛋白、总胆固醇显著高于对照组[（6.52±0.51）%比（5.13±0.34）%,（4.79±1.36）mmol/L比（4.31±1.29）mmol/L],空腹血糖显著低于对照组[（5.61±1.21）mmol/L比（6.23±1.06）mmol/L,P〈0.05];观察组治疗后QOL显著高于对照组[（7.64±1.73）分比（5.29±1.88）分,P〈0.05]。结论肠内营养粉安素能够改善终末期恶性肿瘤患者营养状况,调节糖脂代谢。

Objective To investigate the effects of enteral nutrition powder Ensure on nutritional status and glucolipid metabolism in patients with end- stage malignant tumors. Results 78 cases of patients with end- stage malignant tumors who were admitted in the hospital between August 2012 and August 2014 were included in the study. 28- 72 h after admission, according to whether patients and their families were willing to accept enteral nutrition support through nasojejunal cathetering, the patients were divided into observation group（ 42 cases） and control group（ 36 cases）. The observation group was treated with enteral nutrition powder Ensure while the control group was treated with normal liquid foods,for 30 d; nutritional status,blood glucose and blood lipid indexes in the two groups were evaluated. Quality of life（ QOL） score for cancer patients was issued. Results After treatment, albumin, prealbumin and transferrin in the observation group were significantly higher than those in the control group [（ 30. 16 ± 4. 11） vs（ 22. 11 ± 3. 69） g / L,（ 331. 64 ±26. 34） vs（ 285. 52 ± 27. 85） mg / L,（ 2. 94 ± 0. 58） vs（ 2. 06 ± 0. 71） mg / L ]（ P〈0. 05）. After treatment, glycosylated hemoglobin and total cholesterol in the observation group were significantly higher than those in the control group [（ 6. 52 ± 0. 51） vs（ 5. 13 ± 0. 34） %,（ 4. 79 ± 1. 36） vs（ 4. 31 ± 1. 29） mmol / L ] while fasting blood glucose was significantly lower than that in the control group（ 5. 61 ±1. 21） vs（ 6. 23 ± 1. 06） mmol / L ]（ P〈0. 05）; After treatment,QOL in the observation group was significantly higher than that in the control group [（ 7. 64 ± 1. 73） vs（ 5. 29 ± 1. 88） ]（ P〈0. 05）. Conclusion Enteral nutrition powder Ensure can improve the nutritional status and regulate glucolipid metabolism in patients with end- stage malignant tumors.