肾康注射液对糖尿病肾病合并微量蛋白尿患者胱抑素水平的影响

Influence of Shenkang Injection on Cystatin Levels of Patients with Diabetic Nephropathy Complicated with Microalbuminuria

目的观察肾康注射液治疗糖尿病肾病伴微量蛋白尿的临床疗效,并观察其对患者血清胱抑素水平的影响。方法回顾性分析2013年1月至2015年8月80例糖尿病肾病伴微量蛋白尿患者临床资料,对照组采用常规治疗,如控制饮食、血糖等,观察组在对照组治疗基础上加用肾康注射液治疗,各40例。检测两组患者治疗前后血糖、总胆固醇、三酰甘油、24 h尿蛋白定量、血纤维蛋白原、α微球蛋白及血清胱抑素C变化,并统计两组临床疗效。结果治疗后,两组患者餐后2 h血糖、空腹血糖、总胆固醇、三酰甘油、24 h尿蛋白定量、尿蛋白排泄率、血纤维蛋白原、α微球蛋白及血清胱抑素C水平均较治疗前显著下降,但观察组下降程度较对照组显著(P<0.05);观察组治疗临床总有效率为92.50%,明显高于对照组的67.50%(P<0.05)。结论应用肾康注射液辅助治疗糖尿病肾病伴微量蛋白尿患者,可显著改善其临床指标,从而有利于患者康复。

Objective To observe the efficacy of Shenkang Injection in treating diabetic nephropathy patients complicated with microalbuminuria,and to observe its influence on serum cystatin. Methods A retrospective analysis of 80 cases of diabetic nephropathy with microalbuminuri from January 2013 to August 2015 were conducted,including control group with conventional treatment,such as diet,blood sugar and so on; the observation group, on the basis of the control group, added Shenkang Injection treatment, 40 cases in each group. The blood sugar,cholesterol,triglycerides,24 h urinary protein,fibrinogen,α- microglobulin,serum cystatin C changes were detected before and after treatment,and statistics were made for the clinical efficacy. Results After treatment,the 2 h postprandial glucose,fasting blood sugar, cholesterol, triglycerides,24 h urinary protein, urinary albumin excretion rate, fibrinogen, α- microglobulin, serum cystatin C of the two groups were significantly decreased compared with before treatment,but the observation group decreased more significantly compared with the control group（ P〈0. 05）; the total effective rate in the observation group was 92. 50%, which was significantly higher than 67. 50% of the control group（ P〈0. 05）. Conclusion Shenkang Injection as adjuvant therapy in patients with diabetic nephropathy with microalbuminuria can significantly improve its clinical indicators,thus contributing to the rehabilitation of patients.