围绝经期睡眠障碍肝郁证素与血清5-HT水平及SDS SAS积分的关联研究

Correlation Study of Serum 5-HT and Self-evaluation Scale Scores of Anxiety and Depression of Perimenopausal Nonorganic Insomnia Patients with Liver Depression Syndrome

目的：观察围绝经期非器质性失眠肝郁证患者血清5-HT水平、抑郁自评量表积分（SDS）、焦虑自评量表积分（SAS）的相关性,以期为围绝经期非器质性失眠患者的防治提供思路。方法：纳入围绝经期非器质性失眠肝郁证102例,围绝经期非器质性失眠非肝郁证组80例,比较两组间5-HT、SDS、SAS积分的差异性,分析围绝经期非器质性失眠肝郁证组血清5-HT与抑郁、焦虑自评量表积分之间的相关性。结果：1围绝经期非器质性失眠肝郁证组较非肝郁证组血清5-HT水平差异有统计学意义（P〈0.05）;围绝经期非器质性失眠肝郁证组较非肝郁证组抑郁、焦虑自评量表积分差异有统计学意义（P〈0.05）。2围绝经期非器质性失眠肝郁证组血清5-HT均与SDS积分呈负相关（P〈0.05,相关系数~0.2578）,与SAS积分无相关（P〉0.05）。结论：围绝经期非器质性失眠患者血清5-HT水平可能参与肝郁病机,SDS、SAS积分可作为围绝经期非器质性失眠肝郁的客观参考指标。

Objective： Observing the correlation of serum 5- HT and self- evaluation scale scores of anxiety and depression of perimenopausal nonorganic insomnia patients with or without liver depression; so as to provide thought for the treatment and prevention of perimenopausal nonorganic insomnia. Methods： 102 cases of perimenopausal nonorganic insomnia patients with liver depression syndrome and 80 cases of perimenopausal nonorganic insomnia patients without liver depression syndrome were selected from inpatient and outpatient patients,through statistical methods,the correlation of 5- HT and anxiety and SDS scores of each group as well as the differences of serum in 5- HT,SDS and SAS scores of each group were analyzed. Results： 1. 5- HT level of perimenopausal nonorganic insomnia group with liver depression syndrome decreases more significantly than that of perimenopausal nonorganic insomnia group without liver depression syndrome and the difference was statistically significant（ P〈0. 05）; SDA and SAS scores increase significantly and the difference was statistically significant（ P〈0. 05）. 2. 5- HT level of perimenopausal nonorganic insomnia patients with liver depression syndrome group was negatively correlated with SDS scores（ P〈0. 05,the correlation coefficient was- 0. 2578）; 5- HT level was not correlated with SAS scores（ P〉0. 05）. Conclusion： 1. 5- HT may take part in the pathogenesis of liver depression syndrome in perimenopausal nonorganic insomnia patients. SDA and SAS scores can be as an objective reference index of perimenopausal nonorganic insomnia with liver depression syndrome.