应用HOMA-β与HOMA-IR评价芩连降糖方对2型糖尿病胰岛β细胞功能的影响

Effect of Applying HOMA-β and HOMA-IR to Evaluate the Function of Pancreatic β-cell of T2DM Treated by Qinlian Jiangtang Formula

目的:应用胰岛β细胞功能(HOMA-β)与胰岛素抵抗指数(HOMA-IR),评价芩连降糖方对2型糖尿病患者胰岛β细胞功能的影响。方法:将符合纳入标准的2型糖尿病患者98例,分为治疗组50例,对照组48例,两组基础治疗均给予胰岛素诺和灵30R治疗,治疗组在此基础上加用芩连降糖方,4周为1个疗程,观察3个疗程。观察两组治疗前后血浆胰岛素水平、C-肽水平、HOMA-β、HOMA-IR值的变化以及糖化血红蛋白、胰岛素用量等指标。结果:1治疗组胰岛素、C-肽水平、HOMA-β、HOMA-IR、糖化血红蛋白值,改善较对照组明显;2治疗组胰岛素总量减少,血糖达标时胰岛素用量少且血糖达标时间短。结论:通过HOMA-β与HOMA-IR及其他相关指标的评价,证实芩连降糖方对2型糖尿病胰岛β细胞功能具有一定保护作用,值得推广。

Objective： To investigate the pancreatic β- cell function of T2 DM patients who treated by Qinian Jiangtang Formula. Methods： 98 patients were randomly divided into two groups,namely,the treatment group（ including 50cases） treated by Qinlian Jiangtang Formula combined insulin and the comparison group（ including 48cases） treated by insulin. Both of the two groups were treated for 3period of treatment,which would last 4weeks. Observational index included HOMA- β,HOMA- IR,Hb A1 c,insulin dosage. Results： 1The standard of insulin,C- Peptide,HOMA- β,HOMA- IR,Hb A1 c of the treatment group were improved obviously. 2 The insulin dosage and standard time in the treatment group were reduced significant. Conclusion： Through the assessment of those observational index,we can conclude that Qinlian Jiangtang Formula has protective effect for the function of pancreatic β- cell,worthy of a wide clinical application.