益气健脾化痰方治疗COPD稳定期临床观察及对血清TGF-β1 b-FGF的影响

Clinical Observation of Using Yiqi Jianpi Huatan Recipe in the Treatment of COPD in Stable Stage and the Effect on TGF-β1 and b-FGF in Serum

目的:探讨益气健脾化痰方治疗慢性阻塞性肺疾病(COPD)稳定期的疗效及对血清转移生长因子1(TGF-β1)、碱性成纤维细胞生长因子(b-FGF)的影响。方法:选取医院收治的COPD稳定期患者80例作为研究对象,采用数字随机对照表将患者分为对照组和观察组,各40例,对照组给予西药治疗,观察组在对照组基础上给予益气健脾化痰方治疗,评估2组疗效,对比2组治疗前后肺功能及血清TGF-β1、b-FGF变化,并行中医症状评分。结果:观察组治疗有效率为92.5%显著高于对照组75.0%,差异显著(P<0.05);观察组治疗后咳嗽、咳痰、喘息、气促评分分别为(1.94±0.83)分、(2.10±1.63)分、(1.81±1.03)分、(1.72±1.58)分显著低于对照组,具有统计学意义(P<0.05);观察组治疗后FVC、FEV1、FEV1/FVC分别为(2.65±0.59)L、(1.95±0.63)L、(66.85±3.39)%均显著高于对照组,具有统计学意义(P<0.05);观察组治疗后血清TGF-β1、b-FGF分别为(379.67±27.85)ng/L、(92.21±12.08)ng/L均显著低于对照组,具有统计学意义(P<0.05)。结论:益气健脾化痰方治疗COPD稳定期,可改善气道重塑,疗效确切,

Objective： To investigate the curative effect of the prescription for nourishing Qi to invigorate spleen and reducing phlegm in treating patients with COPD in stable stage and the effect on transforming growth factor 1（ TGF- β1） and basic fibroblast growth factor（ b- FGF） in serum. Methods： 80 patients with COPD in stable stage treated in the hospital were selected as the research objects. According to the digital randomized control table,the patients were randomly divided into the controlled group and the observation group with 40 cases in each group. The controlled group was treated with western medicine,while the observation group was treated with the prescription for nourishing Qi to invigorate spleen and reducing phlegm,on the basis of the controlled group. The efficacy of the 2groups was evaluated. The changes of lung function,TGF- β1and b- FGF in serum in the2 groups before and after the treatment were compared. The TCM syndrome score was performed. Results： The effective rate of the observation group（ 92. 5%） was significantly higher than that of the controlled group（ 75. 0%）（ P〈0. 05）; the scores of coughing,expectoration,wheezing and shortness of breath in the observation group after the treatment were（ 1. 94 ± 0. 83）,（ 2. 10 ±1. 63）,（ 1. 81 ± 1. 03） and（ 1. 72 ± 1. 58）,respectively which were significantly lower than those in the controlled group（ P〈0. 05）; FVC,FEV1 and FEV1 / FVC of the observation group after the treatment were（ 2. 65 ± 0. 59） L,（ 1. 95 ± 0. 63） L and（ 66. 85 ± 3. 39） %,respectively which were significantly higher than those in the controlled group（ P〈0. 05）; After the treatment,the levels of TGF- β1（ 379. 67 ± 27. 85） ng / L and b- FGF（ 92. 21 ± 12. 08） ng / L in serum were significantly lower than those in the controlled group（ P〈0. 05）. Conclusion： The prescription for nourishing Qi to invigorate spleen and reducing phlegm in treating patients with COPD in stable stage can improve airway remodeling and the curative effect is exact.