血吸虫成虫抗宿主凝血机制研究进展

Research Progress on the Mechanisms of Impediment of Blood Coagulation in Host by Adult Schistosomes

血吸虫对宿主初级凝血、次级凝血、血管内皮功能存在干扰作用,对纤维蛋白溶解存在刺激活化作用,说明血吸虫的寄生伴随着复杂的抗凝血机制。本文介绍了国内外有关血吸虫抗宿主凝血机制研究方面的进展,为血吸虫抗体药物及新型生物学抗血栓药物或溶栓药物的研究提供理论依据。

Schistosomes interfere with the primary coagulation, secondary coagulation, and vascular endothelial functions of the host, and activate the fibrinolytic activity, which indicate the presence of anti-coagulation effect during schistosome parasitism. This review introduces research progress on the anti-coagulation mechanisms of schistosomes, in the aim to provide theoretical basis for development of antibodies against schistosome and novel anti-thrombotic or thrombolytic drugs.