婴幼儿血管瘤药物治疗进展

Progress in Pharmacologic Therapy of Infantile Hemangiomas

婴幼儿血管瘤(infantile hemangiomas,IH)是一种最常见的小儿良性肿瘤。大多数患者的血管瘤可随时间增长自行消退,不需干预,但对复杂性血管瘤需尽早治疗以避免严重的并发症。目前研究认为口服普萘洛尔优于传统的激素疗法,是治疗婴幼儿血管瘤的一线方案。本文就糖皮质激素、β受体阻滞剂、干扰素、长春新碱、平阳霉素、咪喹莫特等药物作一概述,希望能为临床选择用药提供参考。

Infantile hemangiomas （IH）are the most common benign tumors in the infants. The majority of infantile hemangiomas regresses spontaneously and do not require a medical intervention. However, complicated infantile hemangiomas require early treatment to avoid significant complications. Nowadays, oral propranolol is considered as first-line therapy for infantile hemangiomas because of its superior efficacy compared to traditional -glucocorticoids. This article reviewed the pharmacologic treatment of IH including the use of steroids, beta-adrenergic blocker, interferon, vincristine, pingyangmycin and imiquimod among others, to provide reference for clinical use of drugs.