摘要
毛囊干细胞(HFSC)通常能够分化为角质细胞、皮脂腺细胞和短暂扩充祖细胞,因其快速增殖的能力,HFSC为细胞的治疗提供了构建干细胞来源的基础。本综述将系统描述HFSC的定位、培养以及分子标志物,为鉴定、分离细胞提供有力的参考。同时针对HFSC增殖和分化调控的关键基因Noggin,从基因发现、分子功能等进行全面阐述,并结合BMP信号通路叙述Noggin调控HFSC研究的最新进展。
Hair follicle stem cells（ HFSCs） normally differentiate into keratinocytes,sebocytes,and transient amplifying progenitor cells. HFSCs have the capacity of rapid proliferation,and thus can provide the basis for establishing a putative source of stem cells for cell therapy. The first section of this review describes the location,culture,and molecular markers of hair follicle stem cells in order to provide a powerful reference for the identification and isolation of cells. The second section of this review presents the discovery and molecular function of Noggin gene which regulates the proliferation and differentiation of HFSCs,and summarizes the advances in regulatory effect of Noggin on HFSCs through BMP signaling pathway.
出处
《实验动物科学》
2016年第1期59-64,共6页
Laboratory Animal Science
基金
国家自然科学基金重点项目(No.31030058)
国家科技支撑计划(No.2011BA115B03)
