肾移植患者应用ELISA方法检测HLA抗体的价值

Application of detection of HLA antibody by ELISA in renal transplantation

目的 探讨ELISA方法检测HLA抗体在临床肾移植中的应用价值。方法 在167例次肾移植受者中应用ELISA方法检测HILA抗体,比较不同抗体水平患者的移植效果及抗体水平在发生排斥反应前后的变化。结果 不同抗体水平组的移植效果有显著性差异(P<0.05)。术后抗体水平变化与急性排斥反应的发生及逆转呈现正则关。结论 ELISA方法检测HLA抗体对于预测移植风险、辅助诊断排斥反应都有较高的临床应用价值。

Objective To evaluate the value of detection of HLA antibody by ELISA in renal transplantation. Methods Variation of HLA antibody level in patients with rejection episode and their outcome were observed and compared. Results Significant difference is observed between different antibody level groups, the variation of antibody level is positively related to the occurence and recovery of acute rejection. Conclusion The detection of HLA antibody by FXISA is valuable in the prediction of transplant risk and in the diagnosis of rejection.