生酮饮食的抗癫痫机制研究进展

Progress of the antiepfleptic mechanisms of ketogenic diet

生酮饮食用于癫痫治疗已达90年之久，引进我国也已10余年。生酮饮食临床疗效已得到一致认可，但其抗癫痫机制至今仍不明确。该文从离子通道、神经递质、神经保护、腺苷及mTOR通路、免疫因素的角度来阐述其可能的抗癫痫机制。

The ketogenic diet has been used for the treatment of epilepsy for 90 years,it also has been introduced to our country for more than 10 years. Its clinical efficacy has been recognized, but its antiepilepsy mechanisms are still unclear. This paper reviews its possible antiepilepsy mechanisms from the ion channels, neu-rotransmitters, neuroprotection, adenosine, mTOR signaling pathway and immune factors.