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Exosome与肿瘤耐药的研究进展

Advances of correlation between exosome and drug resistance of tumor
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摘要 Exosome是直径40-100nm的微囊泡，内含蛋白质、mRNA、microRNA等生物活性物质。机体内几乎所有细胞都可分泌exosome。Exosome不仅是细胞．细胞间物质信息交流的通讯工具，还参与免疫调节、炎症反应、肿瘤发生和耐药等生理病理过程。该文就exosome与肿瘤耐药之间的关系作一综述。 Exosome are nanoparticles released by various cells into extracellular environment, with the diameter of 40-100 nm. Exosome contain different kinds of biological materials, such as proteins, mRNA, microRNA. Exosome can not only mediate cell-to-cell communication, but also be involved in many physiological and pathological processes such as immune response regulation, inflammation, tumorigenesis and drug resistance. This article mainly focuses on correlation between exosome and drug resistance of tumor.
作者 王建玲 鞠秀丽
机构地区 山东大学齐鲁医院儿科
出处 《国际儿科学杂志》 2016年第4期289-291,298,共4页 International Journal of Pediatrics
基金 深圳市科技计划项目（JCYJ20140418115449178） 山东省科技发展计划项目（2013GSF11812）
关键词 EXOSOME 肿瘤 耐药性 Exosome Tumor Drug resistance Fund program： Shenzhen Science and Technology
分类号 R730.2 [医药卫生—肿瘤]
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参考文献23

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国际儿科学杂志
2016年 第4期

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