血清PSA联合直肠指诊诊断前列腺癌的价值

Value of prostate specific antigen and digital rectal examination in diagnosis of prostate cancer

目的 探讨前列腺特异性抗原(PSA)及直肠指诊(DRE)在前列腺癌诊断中的作用。方法 回顾性分析268例前列腺疾病患者的临床资料及PSA、DRE的结果。结果 经病理学确诊14例为前列腺癌,其中PSA值为4.0～9.9μg/L时有5例前列腺癌(5/13),PSA值≥10μg/L有5例前列腺癌(5/7);而DRE可疑者有6例前列腺癌(6/41)。如果单独用PSA或DRE对前列腺癌进行筛选,对前列腺癌诊断的漏诊率分别为28.6％(4/14)、57.1％(8/14),联合使用这两种方法仅有2例漏诊。结论 PSA联合DRE是临床上筛选前列腺癌的可靠方法。

Objective To study the value of prostate specific antigen(PSA) and digital rectal examination (DRE) in diagnosis of prostate cancer. Methods The clinical data and results of PSA and DRE were retrospectively analyzed in 268 cases of prostatic disease. Results Of all the patients. 14 cases were diagnosed as prostate cancer by pathology. There were 5 cases prostate cancer in 13 cases which serum PSA ranged from 4. 0 μg/L to 9.9 μg/L, and 5 cases prostate cancer in 7 cases which scrum PSA levels greater than or equal to 10. 0 μg/L; but there were 6 cases prostare cancer in suspicion by DRE. If PSA or DRE alone were used to screen prostate cancer, 28.6% (4/14), 57.1 % (8/14) would been missed respectively. If PSA combined with DRE were used to detect prostate cancer, only 2 cases would been missed. Conclusion PSA plus DRE is reliable in screen prostate cancer.