老年便秘331例服泻药与结肠黑变病关系的临床分析

The clinical analysis on the relationship between evacuant and melanosis coli in 331 senile patients with constipation

目的 探讨传统的中西药泻剂以及服药时间和方法与老年人结肠黑变病的关系。 方法 总结了我科近 7年住院老年便秘并服用泻剂 3 3 1例患者结肠镜检查结果 ,根据便秘的病程及服用泻药的时间和方法分成4组 ,采用卡方检验分析了服药方式、时间与结肠黑变病的关系。 结果 3 3 1例患者中连续服药≥ 1年者 ,连续服药 <1年者 ,间断服药≥ 1年者和间断服药 <1年者结肠黑变病的发生率分别为 81 0 6% ,77 78% ,11 2 5 %和9 5 2 %。显示连续服药者结肠黑变病发生率明显高于间断服药者 (P <0 0 1) ,而在连续服药者和间断服药者中 ,服药时间长短相差不显著 (P >0 0 5 )。 结论 表明长期服用泻药与老年结肠黑变病的发生有相关性。但结肠黑变病确切的病理变化及临床意义有待进一步研究。

Objective To evaluate the traditional evacuants and the relationship between intake time and method and senile melanosis coli. Methods Three hundred and thirty one in patients with constipation who underwent coloscopy entered this study in recent 7 years .According to intake method and time,the subjects were divided into 4 groups. Results The morbidity of melanosis coli was 81 06% in the group of constipated patients treated with evacuant continuously≥1 year,77 78% in the group treated continuously<1 year,11 25% in the group treated discontinuously≥1 year and 9 25% in the group treated discontinuously<1 year. Conclusions The data Show that taking evacuant continuously is associated with melanosis coli.The definite pathology and the clinical significance of melanosis coli is still unknown.