多囊卵巢综合征患者性激素水平与胰岛素抵抗的相关性研究

Correlationof sex hormones and insulin resistance in polycystic ovary syndrome

目的:探多囊卵巢综合征(PCOS)患者性激素水平与胰岛素抵抗的相关性。方法:选取2013年1月至2014年12月我院收治的多囊卵巢综合征患者40例为研究组,同时选取同期体检健康妇女40例为对照组。检测两组研究对象的睾酮(T)、性激素雌二醇(E_2)、促黄体生成素(LH)以及卵泡刺激素(FSH),并计算LH/FSH的比值;同时检测两组研究对象的空腹血糖(FBG)以及空腹胰岛素(FINS)水平,计算其胰岛素抵抗指数(HOMA-IR),分析HOMA-IR同性激素之间的相关性。结果:研究组HOMA-IR、T、LH以及LH/FSH高于对照组,同时胰岛素敏感指数(ISI)、E_2以及FSH低于对照组,差异显著均有统计学意义(P<0.05);研究组对象的E_2同HOMA-IR呈负相关,同ISI呈正相关(P<0.05);T同HOMA-IR呈正相关,同ISI呈负相关(P<0.05)。结论:PCOS患者存在一定程度的性激素紊乱以及胰岛素抵抗,并且性激素水平同胰岛素抵抗之间存在相关性,共同参与PCOS的发生以及发展,临床上应当予以足够的重视,进一步深入研究。

Objectives：To explore the correlation between sex hormones and insulin resistance in polycystic ovary syndrome （PCOS）.Methods：40 patients with PCOS from January 2013 to December 2014 in our hospital were selected as study group.40 physically health women at the same period were selected as control group.Testosterone （T）,sex hormone estradiol （E2）,luteinizing hormone （LH） and follicle-stimulating hormone （FSH） of the two groups were detected,and the ratio of LH / FSH was calculated.Meanwhile fasting blood glucose （FBG）and fasting insulin （FINS） level of the two groups were detected,the insulin resistance index （HOMA-IR） was calculated,and the correlation between HOMA-IR and sex hormones was analyzed.Results：HOMA-IR,T,LH and LH / FSH in study group were higher than these in control group,while the ISI,E2 and FSH of study groupwere lower than these in control group.The differences were statistically significant （P〈0.05）.In study group,E2 and HOMA-IR were negatively correlated,and E2 and ISI were positively correlated （P〈0.05）;T and HOMA-IR showed a positive correlation and T was negatively correlated with ISI （P〈0.05）.Conclusion：There is a certain degree of hormone disorders and insulin resistance in PCOS patients,and there is a correlation between sex hormone levels with insulin resistance,which is relevant to the occurrence and development of PCOS,and adequate attention should be paid clinically.