高尔基体蛋白73在原发性肝癌诊断中的意义

Significance of golgi protein 73 detection for diagnosis of primary hepatocellular carcinoma

目的探究高尔基体蛋白73在原发性肝癌中的表达水平及对早期诊断的意义。方法收集原发性肿癌(PHC)患者59例为观察组和健康体检者30例为对照组,分别采用酶联免疫吸附试验和化学发光免疫分析法测定两组患者血清GP73和甲胎蛋白(AFP)水平,比较两组间差异,进行统计学分析。结果 PHC患者体内GP73的表达不受年龄、性别、有无乙肝病毒携带、肿瘤大小、有无转移等因素影响,差异无统计学意义(P>0.05)。观察组患者血清中的GP73和AFP水平显著高于正常对照组,差异有统计学意义(P<0.05)。结论 GP73对原发性肝癌的早期诊断具有重要意义,联合AFP诊断更能提高原发性肝癌的诊出率。

Objective To observe the expression level of Golgi protein 73 in primary hepatocellular carcinoma and the significance for early diagnosis. Methods 59 primary hepatocellular carcinoma patients（PHC,group A）and 30 cases of healthy check-up（group B）were collected to observe the changes of GP73 and AFP levels by using methods of ELISA and chemiluminescence immunoassay,and compare the differences between the two groups for statistical analysis. Results The results showed that the levels of GP73 and AFP in group PHC were higher than the group B, and the difference had statistically significant（P〈0.05）. The GP73 expression of PHC patients were not affected by age, gender, presence of hepatitis b virus carrying, tumor size, presence of transfer factors. Conclusion GP73 has the vital clinical significance to the early diagnosis for primary hepatocellular carcinoma.GP73 combined with AFP diagnosis can increase the diagnostic rate of primary hepatocellular carcinoma.