肺炎支原体感染诱发小儿支气管哮喘临床分析

Clinical analysis of infantile bronchial asthma induced by Mycoplasma infection

目的探讨肺炎支原体感染诱发小儿哮喘的临床分析。方法对一汽总医院8 5例支气管哮喘患儿(观察组)和同期2 7例健康体检患儿(对照组)分别采血2 m l送检化验血清肺炎支原体(M P)抗体,进行统计学处理各数据间差异分别采用χ2和t检验,同时对临床资料进行系统性回顾。结果观察组血清M P抗体阳性率为4 5.9%而对照组血清M P抗体阳性率为2 2.2%,提示小儿哮喘患者存在肺炎支原体的感染。结论肺炎支原体感染是诱发支气管哮喘的重要病原体,肺炎支原体既是诱发支气管哮喘发作的感染源,又是过敏源,与哮喘发作有重要关系。当支气管哮喘发作应用常规治疗不能缓解或反复发作时,应注意肺炎支原体感染的可能,需要常规检查M P-I g M,及时加用大环内酯类抗生素如红霉素或阿奇霉素抗炎对于支气管哮喘缓解有明确疗效。

Objective To investigate the clinical analysis of Mycoplasma pneumoniae infection with asthma in children. Methods 2 ml serum was tested for MP antibody in 85 cases of bronchial asthma（observation group）and 27 health children（control group）in our hospital. χ2 test and t test were used for stastical analysis betwen groups. Results Positive rate of MP in serum was 45.9% in Pediatric asthma, an antibody positive rate was 22.2% in ordinary MP control serum, however, the positive rate was 22.2% in the control group, The presence of Mycoplasma pneumoniae in children with asthma. Conclusion Mycoplasma pneumoniae infection is an important pathogen of bronchial asthma, and it is important relationship with asthma attacks. If bronchial asthma can not be relieved or recurrent by using the conventional treatment, it should pay attention to the possibility of infection with Mycoplasma pneumoniae. It should be routinely test to MP-Ig M, and timely add macrolide antibiotics such as erythromycin or azithromycin to alleviate bronchial asthma.