利培酮对精神分裂症首次发病患者认知功能及生活技能的影响

Effects of risperidone on the cognitive function and performance-based skills in drug naive first-episode schizophrenia patients

目的：评估利培酮对精神分裂症首次发病患者认知功能、生活技能改善及影响因素。方法：对首发精神分裂症住院患者105例接受利培酮治疗10周;使用精神分裂症认知功能成套测验中文版（MCCB）、Stroop等测验评估认知功能;加州大学圣地亚哥分校基于任务的生活能力测验（UPSA）评估生活技能;阳性和阴性症状量表（PANSS）评估精神症状。结果：与基线比较,治疗后MCCB中连线分数、符号编码、空间广度、数字序列、迷宫、视觉记忆、情绪管理、MCCB总分、Stroop测验得分均提高,差异有统计学意义（P均〈0.05）;UPSA总分、财务技能、交流技能得分均提高,差异有统计学意义（P均〈0.05）;Logistic Regression回归分析显示MCCB疗效与基线PANSS总分存在关联（β=0.03,Wald=4.80,P=0.028,95%CI1.003～1.057）。结论：利培酮对精神分裂症首次发病患者认知功能及生活技能均有改善作用,认知功能改善程度可能与临床症状无关。

Objective： To evaluate effects of risperidone on the cognitive function and performance-based skills and related influencing factors in drug-naive first-episode schizophrenia patients. Method： One hundred and five inpatients schizophrenia patients received 10 weeks treatment of single reperidone. Patients were assessed with MATRICS consensus cognitive battery（ MCCB）,Stroop,University of Califomia San Diego performance-based skill assessment（ UPSA）,positive and negative syndrome scale（ PANSS）. Results： Compared with baseline,MCCB total score,trail making test,symbol coding,spatial span,digit sequencing,mazes,visuospatial memory,managing emotions and stroop score were significantly increased at week 10（ P all〈 0. 05）. UPSA total score,financial skill and communication skill subscore were significantly increased at week 10 than baseline（ P all〈 0. 05）. Logistic regression showed that MCCB improvement was associated with PANSS total score at baseline（ β = 0. 03,Wald = 4. 80,P = 0. 028,95% CI： 1. 003 ~ 1. 057）. Conclusion： Risperidone can improve cognitive function of patients with first-episode,drug-naive schizophrenia. Improvement of cognitive function could be associated with psychotic symptoms.