盐酸戊乙奎醚预防不停跳冠状动脉移植术高龄患者术后肺部并发症的效果观察

The observation of the protective effects on postoperative pulmonary complications of penehyelidine in elderly patients with off-pump coronary artery bypass grafting

目的:观察盐酸戊乙奎醚预防不停跳冠状动脉移植术高龄患者术后肺部并发症的效果。方法:选择符合入选标准高龄患者(年龄>65岁)90例,根据随机抽样方法决定患者进入盐酸戊乙奎醚试验组(n=45)或0.9%氯化钠液对照组(n=45)。试验组:在麻醉诱导气管插管后静脉缓慢注射盐酸戊乙奎醚20μg/kg(用0.9%氯化钠液稀释至10m L);对照组:在麻醉诱导气管插管后静脉缓慢注射0.9%氯化钠液10m L。结果:90例患者中有27例患者术后出现了肺部并发症,发生率为30%,两组患者术后肺部并发症发生率分别为17.8%(试验组)和42.2%(对照组),其差异有统计学意义(P<0.05)。结论:盐酸戊乙奎醚应用后,有利于围术期呼吸道管理,可显著降低不停跳冠状动脉搭桥术高龄患者术后肺部并发症的发生率。

Objective： To investigate the protective effect of penehyelidine hydrochloride（ PHC） in elderly patients with off-pump CABG. Methods： 90 the elderly patients with off- pump CABG were randomly divided into 2 groups： PHC group（ n = 45） and control group（ n = 45）. Patients in PHC group were given PHC20μg / kg after tracheal intubation. Whereas,patients in control group were given NS in the some dose. Results： Totally there were 27 patients got PPC（ 30%）. Respectively,the incidence of postoperative pulmonary complications was 17. 8%（ PHC group） and 42. 2%,（ control group）. There was significant difference of PPC incidence between two groups. Conclusion： Penehyelidine hydrochloride helps to manage respiratory tract perioperatively. It may reduce the incidence of PPC in elderly patients undergoing off-pump CABG.