男性酒依赖患者注意偏向与戒酒后复饮的相关分析

Correlations between the attentional bias and relapse after abstinence in male alcohol dependent patients

目的研究酒依赖患者对线索词注意偏向特点及与戒酒后复饮的相关性。方法选取46例戒酒初期的酒依赖患者（患者组）以及与其人口学资料相匹配的44名健康对照者（对照组）作为研究对象，采用中文情绪词Stroop任务在戒酒初期进行注意偏向的测试。所有患者戒酒治疗后按月随访。注意偏向与复饮的相关性分析采用Pearson相关分析，戒酒后复饮主要因素筛查采用Logistic多因素回归分析。结果患者组在中性词、负性词、线索词的反应时间[分别为（1411±299）、（1329±318）、（1446±333）ms]高于对照组[分别为（869±278）、（825±213）、（840＋222）ms]，差异有统计学意义（t=8．890、8．800、0．019，均P〈0．01）；患者组对中性词、负性词的错误数[（3．67±2．30）、（3．74±2.31）次]高于对照组[（2．25±2．11）、（2．02±1．80）次]，差异有统计学意义（t=3．053、3．918，均P〈0．01）；在线索词错误数方面2组差异无统计学意义；酒依赖患者持续戒酒时间与负性词的反应时间（r=O．354，P=0．016）和错误数（r=0．442，P=O．004）以及线索词的错误数（r=0．493，P=0．000）呈正相关。结论酒依赖患者对酒相关线索具有显著的注意偏向，这种注意偏向可以作为酒依赖患者戒酒治疗效果预测指标。

Objective To explore the attentional biases to word-related cues in alcohol dependent （AD） patients and the correlations between the attentional bias and relapse after abstinence. Methods A total of 46 AD patients were compared with matched 44 health eontrols（HC） completed the Chinese Emotional Stroop Task that assessed the attentional bias at the beginning of the treatment. Time to relapse was assessed every months during detoxifieation. The correlations between the attentiona] bias and relapse were by Pearson correlation analysis, Logistic regression analysis on risk factors of relapsed after abstinence. Results The reaction time of neutral, negative and alcohol-related words in Chinese Emotional Stroop Task of AD group （ （ 1 411 ± 299）, （1 329±318）, （1 445±333） ms, respectively） was worse than that of HC group （（869±278）, （825±213）, （840±222） ms, respectively）, the difference was statistically significant （t=8.890, 8.800, 0.019, all P〈0.01）. The error number of the neutral and negative-words of AD group（（3.67±2.30）, （3.74±2.31） times） was worse than that of HC group（（2.25±2.11）, （2.02± 1.80） times, t=3.053,3.918, both P〈 0.01）. Time to relapse in AD patients were positively correlated to reaction time and error number of negative-related words, and error number of alcohol- related words （r=O.354,P=0.016; r=0.442,P=0.004; r= 0.493, P=0.000）. Through multiple regression analysis, the error number of the alcohol- related was very import factor. Conclusion The results suggest that patients with alcohol dependence have attentional bias in alcohol-related words as measured by the Chinese Emotional Stroop Task, and alcohol attentional bias could be as a predictor of alcohol abusers＇ treatment outcome.