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MKP-1和MKP-3与疼痛关系的研究进展

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摘要 MKP-1和MKP-3是MAPKs(P38、ERK1/2和JNK)的天然负性调节因子,对MAPKs的去磷酸化作用有重要意义。现已证实MAPKs分子信号通路是疼痛传导的相关通路之一,参与痛觉过敏的触发和维持。已有研究表明通过干扰MKP-1和MKP-3的活性,调节MAPKs信号通路可以减少疼痛。MKP-1和MKP-3能有效缓解疼痛,未来极有可能成为新的镇痛药物靶点和新的研究方向。
作者 杨园园 石翊飒 周海娇
机构地区 兰州大学第二临床医学院 兰州大学第二医院麻醉科
出处 《中国疼痛医学杂志》 CAS CSCD 2016年第4期301-304,共4页 Chinese Journal of Pain Medicine
关键词 MKP-1 MKP-3 MAPKS 疼痛
分类号 R402 [医药卫生—临床医学]
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参考文献28

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二级参考文献74

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中国疼痛医学杂志
2016年 第4期

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