Anatomical changes in the somatosensory system after large sensory loss predict strategies to promote functional recovery after spinal cord injury
Anatomical changes in the somatosensory system after large sensory loss predict strategies to promote functional recovery after spinal cord injury
摘要
Among cases of spinal cord injury are injuries involving the dorsal column in the cervical spinal cord that interrupt the major cutaneous afferents from the hand to the cuneate nucleus（Cu）in the brainstem.Deprivation of touch and proprioceptive inputs consequently impair skilled hand use.
Among cases of spinal cord injury are injuries involving the dorsal column in the cervical spinal cord that interrupt the major cutaneous afferents from the hand to the cuneate nucleus（Cu）in the brainstem.Deprivation of touch and proprioceptive inputs consequently impair skilled hand use.
基金
supported by NIH grants NS067017 to HXQ
NS16446 to JHK
参考文献10
-
1Burton H, Fabri M (1995) Ipsilateral intracortical connections of physio- logically defined cutaneous representations in areas 3b and 1 of macaque monkeys: projections in the vicinity of the central sulcus. J Comp Neurol 355:508-538.
-
2Chand R Jain N (2015) Intracortical and thalamocortical connections of the hand and face representations in somatosensory- area 3b of macaque mon- keys and effects of chronic spinal cord injuries. J Neurosci 35:13475-13486.
-
3Darian-Smith C, Lilak A, Garner J, Irvine KA (2014) Corticospinal sprouting differs according to spinal injury location and cortical origin in macaque monkeys. J Neurosci 34:12267-12279.
-
4Kambi N, Halder R Rajan R, Arora V, Chand R Arora M, Jain N (2014) Large- scale reorganization of the somatosensory cortex following spinal cord injuries is due to brainstem plasticity. Nat Commun 5:3602.
-
5Li CX, Chappell TD, Ramshur IT, Waters RS (2014) Forelimb amputa- tion-induced reorganization in the ventral posterior lateral nucleus (VPL) provides a substrate for large-scale cortical reorganization in rat forepaw barrel subfield (FBS). Brain Res 1583:89-108.
-
6Liao CC, DiCarlo GE, Gharbawie OA, Qi HX, Kaas JH (2015) Spinal cord neuron inputs to the cuneate nucleus that partially survive dorsal column lesions: A pathway that could contribute to recovery after spinal cord inju- ry. J Comp Neurol 523:2138-2160.
-
7Liao CC, Reed JL, Kaas JH, Qi HX (2016) Intracortical connections are al- tered after long-standing deprivation of dorsal column inputs in the hand region of area 3b in squirrel monkeys. J Comp Neurol 524:1494-1526.
-
8Liao CC, Gharbawie OA, Qi H, Kaas JH (2013) Cortical connections to single digit representations in area 3b of somatosensory cortex in squirrel mon- keys and prosimian galagos. J Comp Neurol 521:3768-3790.
-
9Moore CI, Stern CE, Dunbar C, Kostyk SK, Gehi A, Corkin S (2000) Referred phantom sensations and cortical reorganization after spinal cord injury in humans. Proc Natl Acad Sci U S A 97:14703-14708.
-
10Qi HX, Kaas JH, Reed JL (2014) The reactivation of somatosensory cortex and behavioral recovery after sensory loss in mature primates. Front Syst Neurosci 8:84.
-
1Raffaele Nardone,Eugen Trinka.Reorganization of spinal neural circuitry and functional recovery after spinal cord injury[J].Neural Regeneration Research,2015,10(2):201-202. 被引量：1
-
2小虫.电脑能做些什么？[J].大众软件,2006(20):189-190.
-
3赫里斯蒂安·德勒尔.我们怎么知道声音来自哪里？[J].大科技（科学之谜）（A）,2015,0(10):59-59.
-
4Marc Fakhoury.Neural prostheses for restoring functions lost after spinal cord injury[J].Neural Regeneration Research,2015,10(10):1594-1595. 被引量：2
-
5Pierre A.Guertin.Monoaminergic and catecholaminergic activation of the central pattern generator for locomotion following spinal cord injury Innovative therapeutic approaches[J].Neural Regeneration Research,2009,4(10):796-800. 被引量：1
-
6Martin Pohland,Jana Glumm.Propriospinal interneurons in the spotlight for anatomical and functional recovery after spinal cord injury[J].Neural Regeneration Research,2015,10(11):1737-1738.
-
7Benjing Zou,Yongli Zhang,Yucheng Li,Zantao Wang,Ping Zhang,Xiyin Zhang,Bingdong Wang,Zhixin Long,Feng Wang,Guo Song,Yan Wang.Survey of spinal cord injury-induced neurogenic bladder studies using the Web of Science[J].Neural Regeneration Research,2012,7(23):1832-1839. 被引量：3
-
8《科学》：新技术首次获得高分辨率脑干功能图[J].现代生物医学进展,2008,8(4):804-804.
-
9Elisabeth Platzer,Otto Petrovic.An Experimental Deprivation Study of Mobile Phones, Internet and TV[J].Computer Technology and Application,2011,2(8):600-606.
-
10Juan Felipe Diaz Quiroz,Yuping Li,Conrado Aparicio,Karen Echeverri.Development of a 3D matrix for modeling mammalian spinal cord injury in vitro[J].Neural Regeneration Research,2016,11(11):1810-1815.
