枸橼酸莫沙必利联合复方阿嗪米特治疗老年功能性腹胀的疗效及对生活质量的影响

Effects of mosapride combined with compound azintamide on quality of life in the treatment of elderly patients with functional abdominal distension

目的探索枸橼酸莫沙必利联合复方阿嗪米特治疗老年功能性腹胀(FB)的临床效果及对患者生活质量的影响。方法收集老年FB患者共54例作为研究对象,按照就诊先后随机分为2组,其中对照组27例予枸橼酸莫沙必利片,研究组27例予枸橼酸莫沙必利片联合复方阿嗪米特,对比2组腹胀积分变化及生活质量评分差异。结果对照组治疗4周后腹胀积分为(3.30±0.37)分,较治疗前明显降低(P<0.05),但治疗2周时与治疗前比较差异无统计学意义(P>0.05);研究组治疗2周后腹胀积分为(2.31±0.36)分,治疗4周时腹胀积分为(1.20±0.22)分,均较治疗前明显降低(P<0.05),且与对照组同一时间点比较差异有统计学意义(P<0.05)。研究组有效率(92.59%)较对照组(74.07%)明显提高,2组间比较差异有统计学意义(P<0.05)。研究组患者治疗后SF-36量表生理功能、生理职能、躯体疼痛、社会功能、情感职能、精神健康、总体健康及活力等维度评分均较对照组明显提高,2组间比较差异有统计学意义(P<0.05)。结论枸橼酸莫沙必利联合复方阿嗪米特治疗FB疗效显著,可明显改善患者腹胀症状及生活质量。

Objective To explore the effects of mosapride combined with compound azintamide on quality of life in the treatment of senile functional abdominal distension. Methods Fifty-four cases of senile functional abdominal distension were randomly divided into two groups. The control group（ 27 cases） was treated with mosapride citrate mosapride dispersible tablets. The study group（ 27 cases） was treated with mosapride citrate mosapride dispersion tablets combined with compound azintamide. Changes of the abdominal distention score and the quality of life score of two groups were observed and compared. Results The abdominal distension score（ 3. 30± 0. 37） of control group four weeks after treatment decreased significantly compared with before treatment（ P 0. 05）,but there was no significant difference in abdominal distension score between two weeks after treatment and before treatment（ P 0. 05）. The abdominal distension score was 2. 31± 0. 36 two weeks after treatment and 1. 20 ± 0. 22 four weeks after treatment in study group,which were significantly lower than those before treatment（ P 0. 05） and those in the control group（ P 0. 05）. The effective rate of the study group（ 92. 59%） was significantly higher than that in the control group（ 74. 07%）（ P 0. 05）. The SF-36 dimension score of physiological function,physiological functions,bodily pain,social function,role emotional,mental health,general health and activity in the study group after treatment improved significantly than those in the control group（ P0. 05）. Conclusions Mosapride citrate mosapride combined with compound azintamide has significant effect on functional abdominal distension, and it can improve the symptoms and quality of life in patients with abdominal distension.