重型肝炎、活动性肝硬化医院感染预后因素分析

Multivariate Aanlysis for Prognostic Factors of Nosocomial Infection in Severe Liver Diseases

目的 探讨影响重型肝炎、活动性肝硬化患者医院感染预后的危险因素及其防治措施。方法 前瞻性调查 1996年 4月至 2 0 0 0年 12月住院的重型肝炎、活动性肝硬化患者医院感染情况并进行统计分析。结果 重型肝炎、活动性肝硬化医院感染病死率为 37 36 % (34/ 91) ,单因素分析表明血清胆红素、PT、补体C3、血清胆固醇、血钠、白细胞总数、中性粒细胞比例、感染类型、并发症种类、侵袭性操作与预后有相关性 ,多因素分析表明低补体C3及低胆固醇预后严重不良。结论 医院感染是导致重型肝炎、活动性肝硬化患者死亡的重要因素 ,血清低补体C3及低胆固醇是影响预后的高危因素。

Objective To explore the prognostic factors of nosocomial infection in severe hepatitis and liver cirrhosis,and to assess its prevention and treatment.Methods A prospective study of nosocomial infection of severe hepatitis and liver cirrhosis was carried out in our hospital from Apr.1996 to Dec.2000.The prognostic factors of nosocomial infection in severe liver diseases was analyzed by logistic regression.Results The mortality of nosocomial infection in severe liver was 37 36%(34/91).Multiple regression analysis showed that prognosis was in order variables related to follow factors:Serum bilirubin,prothrombin time,complement C3,serum cholesterol,serum sodium,white blood cells count,polymorphonuclear cell rate,the kinds of nosocomial infection,severe complications and improper medical manipulations.The prognostic factors high correlated with nosocomial infection via analysis by logistic analysis were as follows:low serum complement C3 and low cholesterol.Conclusions The nosocomial infection were important factors that cause highly mortality in severe liver diseases.The prognositic factors high related with nosocomial infection of severe liver diseases were:low serum complement C3 and cholesterol level.