肝硬化患者血清FT_3、FT_4浓度变化的临床价值

Evaluation of Clinical Effect of Serum FT_3,FT_4 in Patients With Liver Cirrhosis

目的 研究血清游离甲状腺原氨酸 (FT3) ,游离甲状腺素 (FT4 )浓度变化与肝硬化的关系 ,并探讨其临床意义。方法 用放射免疫法检测了 6 9例肝硬化患者血清FT3、FT4 水平 ,并与肝功能分级 (Child -Pugh积分法 )比较。结果 肝硬化患者血清FT3、FT4 较对照组显著降低 (P <0 0 0 1) ;肝功能A级组血清FT3、FT4 较对照组显著降低 (P <0 0 0 1) ,B级组血清FT3、FT4 较A级组显著降低 (P <0 0 0 1或P <0 0 5 ) ,C级组血清FT3、FT4较B级组显著降低 (P <0 0 5 ) ;肝硬化患者血清FT3、FT4 水平与Child -pugh肝功能分级积分呈负相关 (γ = 0 76 9, 0 72 5 ,P <0 0 1)。结论 随着肝硬化肝功能损害程度的加重 ,血清FT3、FT4 呈下降趋势 ,血清FT3、FT4 水平与肝功能损害程度密切相关。血清FT3、FT4 水平变化对判断肝硬化严重程度 ,指导临床治疗及判断预后具有一定的临床价值。

Objective To study the relationship between changes of contents of serum free-triiodothyronine(FT 3),Free-thyroxine(FT 4) and liver cirrhosis,and analyse it's clinical significanec.Methods The concentration of serum FT 3 and FT 4 were determined by radioimmunoassay in 69 patients with liver cirrhosis,compared with liver function classification(Child-Pugh).Results Contents of serum FT 3,FT 4 in cirrhosis patients were markedly lower than that of controls(P<0 001);contents of serumFT 3,FT 4 in group A degree were markedly lower than that of controls(P<0 001),contents of serum FT 3,FT 4 in group B degree were markedly lower than that in group A degree (P<0 001 or P<0 05),contents of serum FT 3,FT 4 in group C degree were markedly lower than that of group B degree (P<0 05);There was a negative correlation between serum FT 3,FT 4 and liver function classification(Child-Pugh) in patients of liver cirrhosis(γ= 0 796 or 0 725,P<0 01).Conclusions The serum FT 3 and FT 4 decreased gradually with the progression of clinical liver cirrhosis deteriorated degree.There is a significant correlation between FT 3,FT 4 and liver functions.Measuring the concentration of FT 3,FT 4 has utilizable and reliable clinical value in predicting the degree and treatment and prognosis of liver cirrhosis.