微生物菌群在呼吸道疾病中的作用被引量：6

The role of microbiome in respiratory disease

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摘要宏基因组学的不断发展，揭示了微生物菌群在许多疾病的发生和发展中发挥着重要作用。国内外大量研究表明位于鼻咽部、口咽部和（或）肺部的菌群在慢性阻塞性肺疾病（COPD）、哮喘、囊性纤维化（CF）、支气管扩张、上呼吸道感染等呼吸道疾病发生了定性和／或定量的改变，并影响机体的免疫、代谢和神经调节等过程。这些研究成果或将为呼吸道疾病的诊断、治疗、病情监测及预后判断提供新的策略。 The development of metagenomics revealed a novel role of microorganism in lots of diseases Emerging researches at home and abroad illustrated that microbiome changes from nasopharynx, oropharynx and/or lung in quality and/or quantity exist in many respiratory diseases including chronic obstructive pulmonary disease, asthma, cystic fibrosis, pneumonia as well as upper respiratory infection, which play an important role in immune system, metabolism and neuroregulation. These research results may provide us new strategy for the diagnosis, therapy, surveillance and prognosis of respiratory diseases,

作者贺文芳马越云周磊郝晓柯

机构地区第四军医大学附属西京医院全军临床检验医学研究所

出处《中华检验医学杂志》 CAS CSCD 北大核心 2016年第4期322-325,共4页 Chinese Journal of Laboratory Medicine

关键词微生物学呼吸道疾病 Microbiology Respiratory tract diseases

分类号 R56 [医药卫生—呼吸系统]

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1Fnjimura KE, Demoor T, Rauch M, et al. House dust exposure mediates gut microbiome Lactobacillus enrichment and airway immune defense against allergens and virus infection [J]. Proc Natl Acad Sci USA, 2014, 111 (2) : 805-810. DOI: 10. 1073/ pnas. 1310750111.
2Allais L, Kerckhof FM, Verschuere S, et al. Chronic cigarette smoke exposure induces microbial and inflammatory shifts and mucin changes in the murine gut [ J]. Environ Microbiol, 2015 [ Epub ahead of print ]. DOI: 10.1111/1462-2920. 12934.
3Qin N, Yang F, Li A, et al. Alterations of the human gut microbiome in liver cirrhosis [ J ]. Nature, 2014, 513 (7516) : 59-64. DOI: 10. 1038/nature13568.
4Morgan XC, Tickle TL, Sokol H, et al. Dysfunction of the intestinal microbiome in inflammatory bowel disease and treatment [J]. Genome Biol,2012,13(9) :R79. DOI: 10. l186/gb-2012- 13-9-r79.
5Teo SM, Mok D, Pham K, et al. The infant nasopharyngeal microbiome impacts severity of lower respiratory infection and risk of asthma development [ J ]. Cell Host Microbe, 2015, 17 ( 5 ) : 704-715. DOI: 10. 1016/j. chom. 2015.03. 008.
6Handelsman J, Rondon M R, Brady S F, et al. Molecular biological access to the chemistry of unknown soil microbes : a new frontier for natural products [ J ]. Chem Biol, 1998, 5 (10) : R245-R249. DOI: 10. 1016/S1074-5521 (98) 90108-9.
7Ling Z, Liu X, Luo Y, ct al. Pyrosequencing analysis of the human microbiota of healthy Chinese undergraduates[J].BMC Genomics, 2013, 14: 390. DOI: 10. 1186/1471-2164-14-390.
8Bassis CM, Erb-Downward JR, Dickson RP, et al. Analysis of the upper respiratory tract microbiotas as the source of the lung and gastric microbiotas in healthy individuals [ J]. MBio, 2015, 6 (2) : e00037. DOI : 10.1128/mBio. 00037-15.
9Charlson ES, Chen J, Custers-Allen R, et al. Disordered microbial communities in the upper respiratory tract of cigarette smokers[J].PLoS One, 2010, 5(12): e15216. DOI: 10. 1371/journal. pone. 0015216.
10Biesbroek G, Bosch AA, Wang X, et al. The impact of breastfeeding on nasopharyngeal microbial communities in infants [J]. Am J Respir Crit Care Med,2014,190(3) :298-308. DOI: 10.1164/rccm. 201401-0073 OC.