氟伐他汀对肾病综合征患者肾小管功能的影响

Effect of Fluvastatin on the Tubule Function of the Patients With the Nephrotic Syndrome

目的 探讨氟伐他汀对肾病综合征患者肾小管功能的影响。方法 对 5 2例原发性肾病综合征患者 ,采用随机化方法分为实验组和对照组 ,全部采用肾病综合征基本治疗 ,在此基础上 ,实验组加用氟伐他汀(40mg/d)。治疗 8周后测定血浆白蛋白、血肌酐、血脂全套、2 4h尿蛋白定量和尿视黄醇结合蛋白。结果 实验组TG、CH、LDL、尿RBP和尿Pro明显降低 ,血浆Alb明显升高 ,与对照组比较 ,有显著性差异 (P <0 0 5 )。结论 氟伐他汀能有效改善肾病综合征患者的肾小管功能。

Objective To evaluate the effect of fluvastatin on the tubule function of the patients with the nephrotic syndrome. Methods Fifty two patients were divided into the experimental group and the control group at random ,all patients were treated with the standard therapies and fluvastatin was added to the experimental group.Plasma albumin,serum cretinine,serum lipid profiles,24hr urinal protein and urinary RBP were examined before treatment and after 8 weeks in all patients. Results The levels of TG,LDL,CH,urinary RBP,urinary protein after 8 weeks of the treatment were significant lowered than those before the treatment (P<0.05),the level of the plasma albumin was increased ,compared with the control group ,there were significant difference (P<0.05). Conclusion Fluvastatin can effectively ameliorate the renal tubules function of the patients with the nephrotic syndrome.