不同剂量辛伐他汀治疗老年高脂血症疗效及安全性观察

Comparative Study of the Effects and the Safety of Different Dose of Simvastatin on Aged Patients With Hyperlipidemia

目的 观察辛伐他汀 (舒降之 ) 2 0mg与 4 0mg不同剂量对老年高脂血症患者的降血脂疗效及安全性的影响。方法 70例老年高脂血症患者以抽签法随机分为舒降之 2 0mg组 (A组 ,n =4 0 )及舒降之 4 0mg组 (B组 ,n =30 )。观察用药 4周 ,8周 ,12周患者的血清总胆固醇 (TCH) ,低密度脂蛋白胆固醇 (LDL -C) ,高密度脂蛋白胆固醇 (HDL -C)及甘油三酯 (TG)变化。并观察两组患者服药前后肝肾功能、血糖及心肌酶学的变化。结果服用舒降之 2 0mg/d 4周 ,8周及 12周可分别使患者血清TCH降低 32 1%、32 1%、36 0 % ,TG降低 35 1%、4 9 6 %、5 2 9% ,LDL降低 39 3%、37 3%、35 2 % ,HDL -C升高 2 0 %、0 8%、8 3%。服用舒降之 4 0mg/d 4周 ,8周及 12周可分别使患者血清TCH降低 4 1 8%、4 8 0 %、5 1 0 % ,TG降低 18 4 %、32 3%、38 4 % ,LDL降低4 2 4 %、4 7 5 %、5 0 8% ,HDL -C升高 1 0 %、2 0 %、13 0 %。两种剂量药物治疗前后肝肾功能、血糖及心肌酶学无显著性差异。结论 每日口服舒降之 2 0mg与 4 0mg比较疗效基本相同 ,且安全性一致。

Objective To investigate the effects and the safety of different dose of simvastatin on aged patients with hyperlipidemia.Method The 70 patients were divided into two groups at random. 40 in group A was given orally simvastatin 20 mg/d, and 30 patients in group B was given orally simvastatin 40 mg/d,respectively; The levels serum total cholesterol(TCH), low-density lipoprotein cholesterol(LDL-C), high-density lipoprotein cholesterol(HDL-C) and triglyceride(TG) were measured following the 4th week, the 8th week and the 12th week . And the changes of the functions of the patients'liver and kidney, the serum glucose level and the activities of myocardial enzymes in the two groups before and after the simbastatin treatment were also observed. Results In the 4th , 8th and 12th week at the treatment with simvastatin 20mg/d, the patients' TCH levels were decreased by 32 1%,32 1%,36 0% respectively;the TG levels were decreased by 35 1%,49 6%,52 9% respectively;the LDL levels were decreased by 39 3%,37 3%,35 2% respectively;and the HDL-C levels were increased by 2 0%,0 8%,8 3%, respectively. While in the 4th, 8th and 12th week at the treatment of simvastatin 40mg/d,the patients' TCH levels were decreased by 41 8%,48 0%,51 0%, TG levels were decreased by 18 4%,32 3%,38 4%, the LDL levels were decreased by 42 4%,47 5%,50 8%, and the HDL-C levels were increased by 1 0%,2 0%,13 0% respectively. There were no obviously changes of the results of the tests of the liver function,the kidney function,the blood glucose level and the myocardial enzymes before and after both treatment groups in the different dose of the simvastain. Conclusion The effects and the safety of the treatments of simvastatin on aged patients with hyperlipidemia were similar at the dose of 20mg/d and the dose of 40mg/d.