摘要
目的检测口腔鳞癌中上皮间质化(EMT)相关蛋白和β-连环素(β-catenin)的表达初步探讨其意义。方法用免疫组法检测32例口腔鳞癌组织及正常组织中上皮标记物:上皮-钙黏蛋白(E-cad)及细胞角蛋白(CK)、β-catenin的表达。结果口腔鳞癌组β-catenin表达明显高于正常组织组(P<0.05),CK及E-cadherin表达明显低于正常组织组(P<0.05);β-catenin在T4+T3组的表达显著高于T1+T2组(P<0.05),E-cadherin的表达明显低于T1+T2组(P<0.05);有淋巴结转移组β-catenin表达高于无淋巴结转移组(P<0.05),E-cadherin、CK表达低于无淋巴结转移组(P<0.05)。结论口腔鳞癌组织中存在EMT现象,E-cadherin、CK及β-catenin在OSCC与正常组织表达中有差异,β-catenin可能参与OSCC组织发生EMT的进程,促进口腔鳞癌浸润及转移。
Objective To investigate the expression and clinical significance ofβ-catenin and EMT correlated protein.Methods 32 cases of OSCC and 10 cases of nomal human were detected by IHC to explore the expression ofβ-catenin and epithelial drived markers which were E-codherin and Cytokeratin.Results The expression ofβ-catenin in is significantly higher than that in the normal group（P〈0.05）;and the expression of Cytokeratin and E-cadherin is significantly lower than those in the normal group（P〈0.05）;the expression ofβ-catenin in T3＋T4group is higher than T1＋T2group（P〈0.05）,The expression of E-cadherinis significantly lower than T1＋T2Group（P〈0.05）.The expression ofβ-catenin is higher than the group without lymph node metastasis（P 0.05）.The expression of E-cadherin,Cytokeratin and is lower than the group without lymph node metastasis（P 0.05）.Conclusion EMT takes place in OSCC.E-codherin,Cytokeratin andβ-catenin are differently expressed in OSCC and normal epithelial tissue.β-catenin may involve the progression of EMT in OSCC,promote infiltraton and metastasis of OSCC.
出处
《贵州医药》
CAS
2016年第3期236-238,共3页
Guizhou Medical Journal
基金
贵阳市卫生局科学技术计划项目(2014筑卫科技合同字第15号)
贵州省科技计划课题任务(黔科合LG字[2011]001号)
