摘要
目的检测食管鳞癌及其癌旁组织和食管正常组织的中Gli-1的表达水平,并探究其与食管鳞癌的临床及病理因素之间的关系。方法免疫组化法测36例食管癌及其癌旁组织和9例食管正常组织Gli-1表达水平。结果 Gli-1在食管鳞癌阳性表达率为55.6%;癌旁为13.9%;食管正常组织中为11.1%;组间差异有统计学意义(P〈0.05);Gli-1在癌旁和正常组织中均显著低于鳞癌(P〈0.05);Gli-1在癌旁和正常食管中表达差异无统计学意义(P〉0.0 5)。其阳性表达率在Ⅰ~Ⅱ期远低于Ⅲ~Ⅳ期(P〈0.05),T1~T2远低于T3~T4(P〈0.05),无淋巴转移的远低于转移(P〈0.05)。但其表达与年龄、性别、肿瘤位置、直径及分化程度无关(P〉0.05)。结论 Gli-1参与了食管鳞癌的发展进程,高表达的Gli-1可能是促进食管鳞癌浸润转移的因素之一。
Objective: Objective To observe the expression of Gli- 1 in esophageal squamous cell carcinoma( ESCC),tumor- adjacent tissues and normal tissues,and to investigate the expression and clinical significance of Gli- 1 protein in esophageal squamous cell carcinoma. Methods: The expression of Gli- 1 protein was detected by immunohistochemistry in36 cases ESCC,tumor- adjacent tissues and 9 cases normal esophageal tissues. Results: In esophageal squamous cell carcinoma,tumor- adjacent tissues and normal tissues,the positive expression rate of Gli- 1 were 55. 6%,13. 9%,and11. 1% respectively,there was significant difference between group( P〈 0. 05). The expression of Gli- 1 protein in tumor- adjacent and normal tissues was lower than that in esophageal squamous cell carcinoma. The difference was statistically significant( P〈 0. 05). No difference was found between tumor- adjacent and normal tissues about the expression of Gli- 1 protein( P〈 0. 05). The expression of Gli- 1was not only much lower in T1 ~ T2 than that in T3 ~ T4( P〈 0. 05)but also much lower in clinical stage Ⅰ ~ Ⅱ than that in Ⅲ ~ Ⅳ( P〈 0. 05). The expression of Gli- 1 was higher in nodal metastases group than that in group without nodal metastases( P〈 0. 05). No correlations were found between Gli-1 protein and age,gender,tumor location,Tumor diameter,the degree of differentiation( P〉 0. 05). Conclusions: Up-regulation of Gli- 1 might be involved in the development of esophageal squamous cell carcinoma,and it might play a promoting role in the invasion and metastasis of esophageal squamous cell carcinoma.
出处
《泰山医学院学报》
CAS
2016年第2期121-123,共3页
Journal of Taishan Medical College