神经生长因子及其受体在卵巢癌中表达

Nerve growth factor and its receptor expression in ovarian cancer

目的研究神经生长因子及其受体在卵巢癌中的作用,为今后临床实践提供参考和借鉴,提高对卵巢癌的早期治疗和防治。方法选取2012年1月～2013年1月期间我院收治的64例卵巢肿瘤患者为研究对象,同时在再选择13例健康者的卵巢组织为对照组进行研究,探讨神经生长因子及其受体在卵巢癌中的作用。结果卵巢癌组神经因子及其受体的表达为87.8%、75.6%,明显高于对照组的15.4%,7.7%,P〈0.05,差异具有统计学意义。结论神经生长因子及其受体在卵巢癌的发展过程中起着十分重要的作用,通过多种机制参与卵巢癌血管生成、浸润以及转移等,神经生长因子及其受体可以作为预测卵巢癌转移以及预后的重要指标,值得在临床实践中广泛推广。

Objective： to study the role of nerve growth factor and its receptor in ovarian cancer,providing a reference for future clinical practice,improve the early treatment and prevention of ovarian cancer. Methods： from January 2012 to January 2012,our hospital during the period of 64 cases of ovarian cancer patients as the research object,at the same time to choose ovarian tissue of 13 cases of healthy subjects as control group,to explore the role of nerve growth factor and its receptor in ovarian cancer. Results： nerve factor and its receptor expression of ovarian cancer group was 87. 8%,75. 6%,significantly higher than the control group 15. 4%,7. 7%,P 〈0. 05,the difference is statistically significant. Conclusion： nerve growth factor and its receptor in the development of ovarian cancer plays a very important role in the process,through a variety of mechanisms involved in ovarian cancer angiogenesis,invasion and metastasis,nerve growth factor and its receptor can serve as important indicators of ovarian cancer metastasis and prognosis,is worth popularizing widely in clinical practice.