中药和天然药物治疗三阴性乳腺癌的实验研究进展

Update of Experimental Research of Traditional Chinese Medicine and Nature Medicine used for Treatment of Triple Negative Breast Cancer

三阴性乳腺癌是一个较为难治的特殊类型的乳腺癌亚型,患者往往临床预后很差。近年来,国内外积极开展针对三阴性乳腺癌的中医药和天然药物的研究。本综述了回顾中医药和天然药物治疗三阴性乳腺癌实验方面的进展,结果提示,一些中药和天然药物的成分可以通过多种途径抑制三阴性乳腺癌细胞的生长和增殖,同时也提示对抑制肿瘤转移的影响、对耐药的作用、对激素受体的影响等方面的研究比较缺乏,药效学的研究也有待加强,复方治疗的研究也亟待关注。

Triple-negative breast cancer（TNBC）is a special, difficult to teat subtype in breast cancer, the clinical outcome of patients is always poor. In recent years, active researches were initiated in China and abroad. Experimental researches of traditional Chinese medicine and nature medicine on treating triple-negative breast cancer were review in this article. Results indicated some ingredients in traditional Chinese Medicine and nature medicine could inhibit tumor growth and proliferation of TNBC by multiple channels. It also indicated that researches on effect of tumor metastasis inhibition, drug resistance, and hormone receptors were still lack, pharmaeodynamies study need to be enhanced, research of complex prescription should be paid attention to.