中药治疗人类乳头瘤病毒亚临床感染的疗效观察及对T细胞亚群的影响

Effect of Treatment by Chinese Herbs for Subclinical Papillomavirus Infection( SPI) and Change of T cell Subpopulation

目的:观察中医辨证、中药治疗HPV亚临床感染的疗效,并探讨治疗对患者T淋巴细胞亚群的影响。方法:将HPV亚临床感染患者68例随机分为两组。治疗组34例,根据中医辨证遣方用药,水煎内服外洗;对照组34例,宫颈SPI患者用重组人干扰素α-2b阴道泡腾胶囊塞阴道治疗,其他部位SPI患者口服盐酸左旋咪唑片治疗。结果:(1)治疗组总有效率为64.71%,对照组为38.24%。两组比较,差异有统计学意义(P<0.05)。(2)治疗组治疗前后的CD3、CD4及CD8比较,差异无统计学意义(P>0.05)。结论:本研究提示中药治疗HPV亚临床感染的临床疗效较好,中药治疗对HPV亚临床感染患者的外周血T淋巴细胞亚群无明显影响。

Objective： To observe the clinical effect of treatment by Chinese herbs for subclinical papillomavirus infection and the change of T cell subpopulation. Methods： Sixty-eighty cases of subclinical papillomavirus infection patients were randomly divided into two groups. Thirty-four cases in treatment group were treated by Chinese herbs taken orally and washout and the other34 cases in control group. The SPI at cervix was treated by IFN caps putting in vagina and others were treated by Levamisole orally. Results： The total effective rate was 64. 71% in treatment group and 38. 24% in control group. There was significant difference between the two groups（ P 0. 05）. Conclusion： The clinical effect of Chinese herbs for subclinical papillomavirus infection is better. The change of T cell subpopulation is not significant.