芪蛭通络胶囊治疗血管性轻度认知障碍的疗效观察

Qizhi Tongluo Capsule in Treatment of Vascular Cognitive Impairment

目的:评价芪蛭通络胶囊治疗血管性认知障碍的临床疗效。方法:本研究从本院脑病科门诊及住院招募血管性认知功能障碍(VCI)患者60例,随机分为A、B两组,各组30例。A组口服尼莫地平每次30 mg,3次/d,共治疗3个月;B组在A组基础上加口服芪蛭通络胶囊每次800 mg,2次/d,疗程总共3个月。比较VCI患者治疗前后简易智能精神状态量表(MMSE)、日常生活能力量表(ADL)的变化。结果:A组治疗前后MMSE评分、ADL评分比较差异有统计学意义(均P<0.01);B组治疗前后MMSE评分、ADL评分比较差异有统计学意义(均P<0.01);B组和A组治疗后MMSE评分、ADL评分比较差异有统计学意义(均P<0.01)。结论:芪蛭通络胶囊能够改善血管性认知障碍(VCI)患者的认知功能。

Objective： To assess the efficacy of Qizhi Tongluo Capsule in vascular cognitive impairment（ VCI）. Methods： Sixty patients with VCI from encephalopathy department outpatient and inpatient were randomly divided into A group（ n = 30） and B group（ n = 30）. A group were treated with nimodipine（ 1 table,tid） and B group with Qizhi Tongluo Capsule combined nimodipine（ 2 tables,bid）. The duration of therapy was three months. MMSE and ADL were used to evaluate the outcome. Results： The MMSE scores and ADL scores of A group before and after treatment had significant difference（ P〈0. 01）. The MMSE scores and ADL scores of B group before and after treatment had significant difference（ P〈0. 01）. The MMSE scores and ADL scores of two groups after treatment were significant（ P〈0. 01）. Conclusion： Qizhi Tongluo Capsule may improve the cognitive function in patients with VCI.