Calcitonin and vitamin D3 have high therapeutic potential for improving diabetic mandibular growth 被引量：1

Calcitonin and vitamin D_3 have high therapeutic potential for improving diabetic mandibular growth

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摘要 The goal of this study was to assess the effect of the intermittent combination of an antiresorptive agent （calcitonin） and an anabolic agent （vitamin D3） on treating the detrimental effects of Type 1 diabetes mellitus （DM） on mandibular bone formation and growth. Forty 3-week-old male Wistar rats were divided into four groups： the control group （normal rats）, the control C＋D group （normal rats injected with calcitonin and vitamin D3）, the diabetic C＋D group （diabetic rats injected with calcitonin and vitamin D3） and the diabetic group （uncontrolled diabetic rats）. An experimental DM condition was induced in the male Wistar rats in the diabetic and diabetic C＋ D groups using a single dose of 60 mg.kg-1 body weight of streptozotocin. Calcitonin and vitamin D3 were simultaneously injected in the rats of the control C＋D and diabetic C＋D groups. All rats were killed after 4 weeks, and the right mandibles were evaluated by micro-computed tomography and histomorphometric analysis. Diabetic rats showed a significant deterioration in bone quality and bone formation （diabetic group）. By contrast, with the injection of calcitonin and vitamin D3, both bone parameters and bone formation significantly improved （diabetic C＋ D group）（P 〈 0.05）. These findings suggest that these two hormones might potentially improve various bone properties. The goal of this study was to assess the effect of the intermittent combination of an antiresorptive agent （calcitonin） and an anabolic agent （vitamin D3） on treating the detrimental effects of Type 1 diabetes mellitus （DM） on mandibular bone formation and growth. Forty 3-week-old male Wistar rats were divided into four groups： the control group （normal rats）, the control C＋D group （normal rats injected with calcitonin and vitamin D3）, the diabetic C＋D group （diabetic rats injected with calcitonin and vitamin D3） and the diabetic group （uncontrolled diabetic rats）. An experimental DM condition was induced in the male Wistar rats in the diabetic and diabetic C＋ D groups using a single dose of 60 mg.kg-1 body weight of streptozotocin. Calcitonin and vitamin D3 were simultaneously injected in the rats of the control C＋D and diabetic C＋D groups. All rats were killed after 4 weeks, and the right mandibles were evaluated by micro-computed tomography and histomorphometric analysis. Diabetic rats showed a significant deterioration in bone quality and bone formation （diabetic group）. By contrast, with the injection of calcitonin and vitamin D3, both bone parameters and bone formation significantly improved （diabetic C＋ D group）（P 〈 0.05）. These findings suggest that these two hormones might potentially improve various bone properties.

作者 Mona A Abbassy Ippei Watari Ahmed S Bakry Takashi Ono Ali H Hassan

机构地区 Orthodontic Department Department of Orofacial Development and Function Alexandria University Conservative Dentistry Department Cariology and Operative Dentistry Department Conservative Dentistry Department

出处《International Journal of Oral Science》 SCIE CAS CSCD 2016年第1期39-44,共6页 国际口腔科学杂志（英文版）

基金 the National Plan for Science,Technology and Innovation(MAARIFAH)-King Abdulaziz City for Science Technology-the Kingdom of Saudi Arabia award number(12-MED2735-03) Science and Technology Unit,King Abdulaziz University for technical support

关键词 type 1 diabetes mellitus mandibular bone structure mandibular bone formation micro-computed tomography BONE HISTOMORPHOMETRY type 1 diabetes mellitus mandibular bone structure mandibular bone formation micro-computed tomography bone histomorphometry

分类号 R587.1 [医药卫生—内分泌] R782 [医药卫生—口腔医学]

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