胃部幽门螺杆菌感染对口腔异味患者的临床意义

Correlation between bad breath and Helicobacter pylori infection

目的:探讨口腔异味(又称口臭)的发生与胃部幽门螺杆菌(Helicobacter pylori,H.pylori)感染的相关性.方法:随机选择2014-08/2015-11因消化系统疾病或者健康体检来庆元县人民医院和丽水市人民医院就诊236例患者为研究对象,通过鼻嗅法分为口腔异味组和无口腔异味组,所有患者均行^(14)C呼气试验,根据有无H.pylori的感染,比较两组H.pylori的感染率.根据患者胃部是否有H.pylori感染,分为感染组和无感染组,分别比较两组患者口腔异味的发生率,根据结果探讨分析口腔异味的发生与胃部H.pylori感染的相关性.结果:236例研究对象中,口腔异味组109例(46.19%),其中胃H.p y l o r i阳性74例(67.89%);无口腔异味组127例(53.81%),其中胃H.pylori阳性36例(28.35%);两组间比较差异有统计学意义(χ~2=31.53,P<0.05),口腔异味与胃部H.pylori感染的相关系数r=0.33.H.pylori感染阳性135例(57.20%),其中口腔异味者有93例(68.89%);H.pylori检测阴性101例(42.80%),其中口腔异味者有4例(3.96%);两组间比较差异有统计学意义(χ~2=52.57,P<0.05),H.pylori感染与口腔异味发生率间的相关系数r=0.61.结论:有口腔异味的患者,大多数存在胃部H.pylori的感染,胃部H.pylori感染的患者有较高的口腔异味发生率,因此口腔异味与H.pylori感染两者之间存在密切的相关性,H.pylori感染是引起口腔异味的一个重要原因,要引起重视.

AIM： To assess the correlation between bad breath（also known as halitosis） and Helicobacter pylori（H. pylori） infection.METHODS： A total of 236 patients or healthy volunteers were randomly seleted. Based on the presence of halitosis or not, the subjects were divided into a halitosis and a no-halitosis group. All patients underwent 14C-urea breath test, and according to the presence of H. pylori infection or not, the subjects were divided into a H. pylori infection group and a no-infection group. The incidence of halitosis in the H. pylori infection and no-infection groups was compared, and the correlation of H. pylori infection with halitosis was analyzed. RESULTS： Of the 236 subjects included, 109（46.19%） had halitosis, including 74（67.89%） who were positive for H. pylori infection, and 127（53.81%） had no halitosis, including 36（28.35%） who were positive for H. pylori infection.The rate of H. pylori infection between the two groups was statistically significant（χ2 = 31.53, P 〈 0.05）, and there was a significant correlation between halitosis and H. pylori infection（r = 0.33）. There were 135（57.20%） H. pylori positive cases, of which 93（68.89%） had halitosis. There were 101（42.80%） H. pylori negative cases, of which only 4（3.96%）had halitosis. The rate of halitosis between the two groups was statistically significant（χ2= 52.57, P 〈 0.05）, and there was a significant correlation between H. pylori infection and halitosis（r = 0. 61）. CONCLUSION： In people with halitosis,many have H. pylori infection, and in H. pylori positive people, many have halitosis. There is a close correlation between H. pylori infection and halitosis.