右美托咪定复合酒石酸布托啡诺用于机械通气患者镇痛效果评价

Evaluation of analgesic effect by dexmedetomidine combined with butorphanol tartrate for mechanical ventilation patients

目的探究右美托咪定复合酒石酸布托啡诺对机械通气患者的临床镇痛效果。方法 60例行机械通气的患者随机分为试验A组与试验B组,各30例。对试验A组患者采用右美托咪定复合酒石酸布托啡诺镇痛治疗方案,对试验B组采用咪达唑仑复合酒石酸布托啡诺镇痛治疗方案,对两组患者镇痛时间、用药后唤醒时间及发生谵妄情况进行比较,同时记录两组患者治疗前及治疗后心率、呼吸及血压水平。结果试验A组患者镇痛时间、用药后唤醒时间、谵妄情况发生率均低于试验B组,差异有统计学意义(P<0.05);试验A组患者治疗后心率及血压降低幅度均高于试验B组,差异有统计学意义(P<0.05),但A组血压仍处于较安全水平;两组患者呼吸频率差异无统计学意义(P>0.05)。结论对机械通气患者采用右美托咪定复合酒石酸布托啡诺进行镇痛,具有起效快、患者易唤醒等优点,且安全性较高。

Objective To investigate clinical analgesic effect by dexmedetomidine combined with butorphanol tartrate for mechanical ventilation patients. Methods A total of 60 patients receiving mechanical ventilation were randomly divided into experimental group A and experimental group B, with 30 cases in each group. The experimental group A received dexmedetomidine combined with butorphanol tartrate for analgesia, and the experimental group B received midazolam combined with butorphanol tartrate for analgesia. Analgesia time, post-administration wake up time and occurrence of delirium were compared between the two groups. Records were made on heart rate, breath and blood pressure levels before and after treatment in both groups. Results The experimental group A had all lower analgesia time, post-administration wake up time and incidence of delirium than the experimental group B, and the difference had statistical significance（P〈0.05）. After treatment, the experimental group A had higher reducing level of heart rate and blood pressure than the experimental group B, and their difference had statistical significance（P〈0.05）, while group A had blood pressure at safety level. The difference of respiratory rate had no statistical significance between the two groups（P〈0.05）. Conclusion Implement of dexmedetomidine combined with butorphanol tartrate in mechanical ventilation patients for analgesia can show advantages of quick onset and easy wake up, along with high safety.