摘要
ObjectiveTo 调查一根自我开发的新奇多电极 radiofrequency 脱离导管(火花) 的安全和功效因为 14 头试验性的缩小的猪全部的基于导管的肾的 denervation (RDN ).MethodsA 随机被划分成四个组(55 °； &；5 瓦特， 55 °； &；8 瓦特， 65 °； &；5 瓦特，和 65 °；&；8 瓦特组) 。火花被用于左和恰好肾的动脉 radiofrequency 脱离。象肾的动脉X线摄影法一样从肾的动脉和静脉收集的血样品以前在所有动物上被执行，立即在以后，并且在过程到以后的三个月评估血浆高血压蛋白原酶的火花 on the levels 的效果，醛固酮，血管收缩素我，并且象肾的 arteries.ResultsOne 猪的病理学的变化一样的血管收缩素 II 死于一个麻药事故， 13 头猪成功地经历了双边的肾的动脉脱离。与基本大小相比，在所有四个组的猪显著地减少了在过程以后的吝啬的动脉的压力。组织病理学说的分析证明这个过程能导致内层的增生，在象在 perineurium 的煽动性的细胞渗入和纤维变性那样的肾的动脉的重要外部同情的神经损坏，神经纤维的不平的分发，织物坏死，严重 vacuolization ，碎裂并且不清楚的 nucleoli 髓磷脂退化，稀少的轴突，并且连续性的打断。另外，肾的动脉 radiofrequency 脱离能显著地减少血浆高血压蛋白原酶的层次，醛固酮，血管收缩素我，和在 pigs.ConclusionsThe 结果的血管收缩素 II 建议那基于导管的 radiofrequency 脱离能有效地移开的这类多电极外部肾的同情的神经和还原剂在猪的全身的高血压蛋白原酶血管收缩素系统的活动，因此在猪便于全身的血压的控制。
Objective To investigate the safety and efficacy of a self-developed novel multi-electrode radiofrequency ablation catheter （Spark） for catheter-based renal denervation （RDN）. Methods A total of 14 experimental miniature pigs were randomly divided into four groups （55°＆ 5-watt, 55°＆ 8-watt, 65°＆ 5-watt, and 65° ＆ 8-watt groups）. Spark was used for left and right renal artery radiofrequency ablation. Blood samples collected from renal arteries and veins as well as renal arteriography were performed on all animals before, immediately after, and three months after procedure to evaluate the effects of Spark on the levels of plasma renin, aldosterone, angiotensin I, and angiotensin II as well as the pathological changes of renal arteries. Results One pig died of an anesthetic accident, 13 pigs successfully underwent the bilateral renal artery ablation. Compared with basic measurements, pigs in all the four groups had significantly decreased mean arterial pres- sure after procedure. Histopathological analysis showed that this procedure could result in intimal hyperplasia, significant peripheral sympa- thetic nerve damage in the renal arteries such as inflammatory cell infiltration and fibrosis in perineurium, uneven distribution of nerve fibers, tissue necrosis, severe vacuolization, fTagmented and unclear nucleoli myelin degeneration, sparse axons, and interruption of continuity. In addition, the renal artery radiofrequency ablation could significantly reduce the levels of plasma renin, aldosterone, angiotensin I, and angio- tensin II in pigs. Conclusions The results suggest that this type of multi-electrode catheter-based radiofrequency ablation could effectively remove peripheral renal sympathetic nerves and reduce the activity of systemic renin-angiotensin system in pigs, thus facilitating the control of systemic blood pressure in pigs.
