CD44v6与非小细胞肺癌的研究进展

Research progress of CD44v6 in non - small cell lung cancer

CD44是一种跨膜糖蛋白，是由单一基因所编码的具有高度特异性的单链膜表面糖蛋白家族。其主要参与细胞与细胞、细胞与基质之间的特异性黏附过程。CD44v6是CD44家族的成员之一，其与非小细胞肺癌转移和预后的相关性成为近几年来研究的一大热点，本文就当前CD44v6与非小细胞肺癌的研究进展做一综述。

CD44 is a transmembrane glycoprotein,which is a family of highly specific single chain mem- brane surface glycoproteins by a single gene. CD44 is mainly involved in the specific adhesion between cells and cells, cells and matrix. CD44v6 is a member of the CD44 family, and its correlation with metastasis and prognosis of non small cell lung cancer（NSCLC）has become a hot research topic in recent years. The current research pro- gress of CD44v6 and NSCLC are reviewed in this paper.